The vascular system is involved in the distribution of blood flow to the tissues, as well as in the blood pressure control. Local mechanisms such as myogenic, endothelial, perivascular adipose tissue secretion and innervation, components of extracellular matrix are implicated in the regulation of vascular tone and structure, thereby controlling vascular resistance and compliance. It is well known that dysfunction of above mechanisms is involved in changes on arterial and venous tone and/or structural remodeling, that are pivotal to the pathophysiology of several cardiometabolic diseases, such as hypertension, heart failure, diabetes, and obesity.
According to the World Health Organization, cardiovascular diseases are the major cause of chronic deaths worldwide. Multiple factors such as gender, physical inactivity, genetic, disturbances to the microbiome, and environmental factors such as stress, alcohol consumption, unhealthy diet, air pollution, and contaminants can trigger or modulate cardiovascular disorders. All these factors can direct or indirectly induce vascular dysfunction, thereby contributing to the progression of cardiovascular diseases and, consequently, leading to end-organ target complications.
Several approaches have been traditionally used to prevent or reverse vascular dysfunction associated to cardiovascular diseases. In addition to pharmacological therapy, alterations in eating habits and lifestyle are undoubtedly the most important non-pharmacological interventions in the prevention and treatment of cardiovascular diseases. Enhanced understanding of pathophysiological mechanisms and the pharmacological and non-pharmacological therapies (dietary approaches and physical training) could identify potential targets to prevent or minimize the vascular dysfunction in cardiovascular diseases.
This Research Topic aims to strengthen the understanding of the local vascular adjustments involved in cardiometabolic diseases. For this, we are interested in original and review papers that highlight the functional and molecular mechanisms of local pathophysiological adjustments involved in changes in vascular tonus, inflammation and remodeling, as well as the therapies for these alterations in cardiometabolic diseases.
The vascular system is involved in the distribution of blood flow to the tissues, as well as in the blood pressure control. Local mechanisms such as myogenic, endothelial, perivascular adipose tissue secretion and innervation, components of extracellular matrix are implicated in the regulation of vascular tone and structure, thereby controlling vascular resistance and compliance. It is well known that dysfunction of above mechanisms is involved in changes on arterial and venous tone and/or structural remodeling, that are pivotal to the pathophysiology of several cardiometabolic diseases, such as hypertension, heart failure, diabetes, and obesity.
According to the World Health Organization, cardiovascular diseases are the major cause of chronic deaths worldwide. Multiple factors such as gender, physical inactivity, genetic, disturbances to the microbiome, and environmental factors such as stress, alcohol consumption, unhealthy diet, air pollution, and contaminants can trigger or modulate cardiovascular disorders. All these factors can direct or indirectly induce vascular dysfunction, thereby contributing to the progression of cardiovascular diseases and, consequently, leading to end-organ target complications.
Several approaches have been traditionally used to prevent or reverse vascular dysfunction associated to cardiovascular diseases. In addition to pharmacological therapy, alterations in eating habits and lifestyle are undoubtedly the most important non-pharmacological interventions in the prevention and treatment of cardiovascular diseases. Enhanced understanding of pathophysiological mechanisms and the pharmacological and non-pharmacological therapies (dietary approaches and physical training) could identify potential targets to prevent or minimize the vascular dysfunction in cardiovascular diseases.
This Research Topic aims to strengthen the understanding of the local vascular adjustments involved in cardiometabolic diseases. For this, we are interested in original and review papers that highlight the functional and molecular mechanisms of local pathophysiological adjustments involved in changes in vascular tonus, inflammation and remodeling, as well as the therapies for these alterations in cardiometabolic diseases.
