About this Research Topic
This Research Topic is intended to attract manuscripts that advance the use of MRI-based CVR parameters in clinical assessments of cerebrovascular health using CO2 as a stimulus. In pursuit of this aim, a better understanding of a number of aspects are needed.
• Methods of administering the CO2 stimulus during MRI (stimulus pattern, apparatus).
• The physiology involved in the vascular response to CO2 and how it reflects regional and/or systemic vascular health.
• Techniques to analyse CVR data in different ways (e.g. speed of response, resistance changes) to provide more information about vascular health.
• Relationships between CVR data acquired using different MRI scan acquisitions and aspects of repeatability and reliability.
• The use of CVR to assess vascular health in various pathologies (e.g. concussion, dementia, Moyamoya).
• Methods of measuring CVR with MRI and a CO2 stimulus.
• Improving the analysis of MRI data to provide more information about CVR.
• Characterizing or modelling the physiology involved in the vascular response to CO2 and how this reflects vascular health
• Using MRI-based CVR to assess vascular health in various pathologies
• Addressing the challenges of repeatability, reliability, and specificity of CVR metrics, including within problematic cohorts, during extreme CO2 stimuli, across research sites, or spanning imaging modalities.
Topic Editor Prof. James Duffin contributed to the development of an automated end-tidal targeting device, RespirActTM and is employed by Thornhill Medical Inc. (Toronto, Canada). RespirActTM is currently a non-commercial research tool assembled and made available by TMI to research institutions to enable CVR studies. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Keywords: Brain, Vasculature, Magnetic resonance imaging, Carbon dioxide
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