About this Research Topic
Autoimmune diseases and the immune response to infection and cancer are thought to have both a genetic and environmental predisposition. Among environmental factors, there is mounting evidence that the gut microbiome, a collection of trillions of microorganisms in the gut, plays an important role in disease initiation, maintenance and recovery. The gut is thought to communicate with other organ systems, such as the circulatory, respiratory, digestive, endocrine and nervous systems, through microbial metabolites, immune system messengers, endocrine factor, host-microbiome interactions and dysbiosis.
A better understanding of the mechanisms governing the constituents of the gut microbiome, their shifts during health and disease, sex and ethnic difference and the precise communication lines between the gut and other organs is needed. This will allow for the development of new therapeutics that can target the gut microbiota towards protective, anti-inflammatory phenotypes in various autoimmune and immune-mediated conditions.
The aim of this Research Topic is to cover promising, recent, and novel research related to the gut microbiome and its interactions with the immune system and end-organ communication across the spectrum of autoimmune and immune-mediated conditions.
We welcome the submission of Mini-Review, Review, Original Research and Perspective articles focusing on, but not limited to, the following sub-topics:
• Microbiome-immune homeostasis and regulation of the immune response
• Microbiome and blood brain barrier function in autoimmune disorders and immune-mediated conditions
• Gut microbiome and immune system in autoimmune disorders and immune-mediated conditions
• Gut microbiome, metabolites and endocrine factors in autoimmune diseases and immune-mediated conditions
• Microbial metabolites in health and disease
• Gut-brain axis in neuroinflammatory disorders
• Gut microbiome in rheumatological, liver and lung disorders
• Sex and ethnic differences in gut microbiome
• Microbiome interventions including diet, supplements, clinical trials and therapies
Keywords: microbiome, autoimmunity, immune response, homeostasis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.