About this Research Topic
Early identification of AECOPD has to be among the central strategies for COPD care, and we need effective tools for that. Up to now, there are some questionnaires in use, such as EXACT, CAT, BCSS, and daily diary card. Studies on them are on-going, with the aim of proposing a suitable tool that can be used at the point of care, especially in the primary care settings, to help physicians to detect AECOPD early. However, the cutoff of these questionnaires is not consistent in different studies and cannot reflect the daily variation of symptoms in COPD patients.
In recent years, blood eosinophils have been put to use for prediction of the high-risk population of AECOPD and guiding the steroid usage. However, there is a lack of large sample blood eosinophils data in COPD patients. In addition, defining proper biomarkers using omics methods is of important clinical significance in early diagnosis and management of AECOPD, but we still have a long way to go there.
This Research Topic aims to present the latest progress in the prediction and early diagnosis of AECOPD which include, but are not limited to, the points listed below. We aim to eventually support the prediction of AECOPD and provide guidance on individualized therapy in AECOPD. Original Research Articles and Reviews will be welcome.
- Development and validation of (new) questionnaires
- Development and validation of high-quality prediction models
- Biomarkers and their relationship with the diagnosis, including APRs biomarkers (CRP and neutrophils), etiological biomarkers (PCT), and biomarkers for differential diagnosis (pro BNP or NT-pro-BNP, and X Rays)
- Microbiome and virome in the etiology of AECOPD
Keywords: Prediction, Diagnosis, Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD), Biomarker, questionnaire, Prediction model, microbiome, virome
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