Research Topic

Cardioprotection, Sex and Gender Differences

About this Research Topic

Several studies have reported sex differences in heart susceptibility to cardiovascular diseases. Important and relevant differences in pathophysiology, clinical presentation, and management have been observed between men and women. However, several mechanisms at the basis of these differences are not yet understood. The "sex differences" are due to biological differences, while the "gender differences" are linked to environment, lifestyle, and attitude features. It is emerging that both differences are of fundamental importance in the diagnosis and management of cardiovascular disease (CVD).

All institutions connected with health systems in the western world have increased their level of attention for better reporting of gender specific outcomes in CVD. Mechanistic, epidemiological and clinical studies are needed to understand the sex and gender differences in the pathophysiology and therapy of CVD. This research topic is open to either original research papers or review articles in the area of gender/sex differences and cardiovascular disease.

This Research Topic welcomes review papers and original research around gender/sex differences and cardiovascular disease. It focuses on the following themes but is not limited to them:

• The analysis of the different responses in the ischemic heart disease (IHD) and cardioprotective protocols.
• Diabetes as a more substantial risk for IHD in women compared to men, and cardiometabolic disorders concerning sex differences in CVD.
• The relationship between anthracycline-induced cardiotoxicity and sex.
• Risk factors (e.g. depression and other forms of mental stress (anxiety, anger, work, and marital stress)) which impact differently on women and men.
• Identifying the cellular mechanisms that contribute to sex differences in CVD.
• Sex differences in mitochondrial function and redox signaling as mechanisms underlying cardio-protection.
• Estrogen pathways in pulmonary arterial hypertension.


Keywords: cardiovascular disease, cardioprotection, sex, gender, pathophysiological mechanisms


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Several studies have reported sex differences in heart susceptibility to cardiovascular diseases. Important and relevant differences in pathophysiology, clinical presentation, and management have been observed between men and women. However, several mechanisms at the basis of these differences are not yet understood. The "sex differences" are due to biological differences, while the "gender differences" are linked to environment, lifestyle, and attitude features. It is emerging that both differences are of fundamental importance in the diagnosis and management of cardiovascular disease (CVD).

All institutions connected with health systems in the western world have increased their level of attention for better reporting of gender specific outcomes in CVD. Mechanistic, epidemiological and clinical studies are needed to understand the sex and gender differences in the pathophysiology and therapy of CVD. This research topic is open to either original research papers or review articles in the area of gender/sex differences and cardiovascular disease.

This Research Topic welcomes review papers and original research around gender/sex differences and cardiovascular disease. It focuses on the following themes but is not limited to them:

• The analysis of the different responses in the ischemic heart disease (IHD) and cardioprotective protocols.
• Diabetes as a more substantial risk for IHD in women compared to men, and cardiometabolic disorders concerning sex differences in CVD.
• The relationship between anthracycline-induced cardiotoxicity and sex.
• Risk factors (e.g. depression and other forms of mental stress (anxiety, anger, work, and marital stress)) which impact differently on women and men.
• Identifying the cellular mechanisms that contribute to sex differences in CVD.
• Sex differences in mitochondrial function and redox signaling as mechanisms underlying cardio-protection.
• Estrogen pathways in pulmonary arterial hypertension.


Keywords: cardiovascular disease, cardioprotection, sex, gender, pathophysiological mechanisms


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

18 December 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

18 December 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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