About this Research Topic
Controlled ovarian stimulation (COS) is a complex, longitudinal process inducing a super-physiological cycle, with the objective of obtaining multiple oocytes. In order to maximize treatment efficacy, well-established algorithms should be adopted but also adapted to individual patients' characteristics, taking into account clinical history, age and ovarian reserve. The process of IVF/ICSI consists of 5 sequential steps, which are the actual ovarian stimulation, in order to induce multifollicular development, the ovulation trigger, aiming to induce final oocyte maturation, the egg retrieval, aiming to harvest the matured oocytes, the laboratory procedure, aiming to create embryo, and the embryo transfer, which aims to the transfer of the available embryo(s) inside the uterus.
The objective of the present Research Topic is to give an update on COS, by making an overview of treatment milestones, together with the latest innovations currently being investigated.
This Research Topic calls for original research articles and reviews regarding the understanding of controlled ovarian stimulation, as listed but not limited to the following:
1. Pre-treatment therapies
a. Oral contraceptive pill pre-treatment
b. Progestogen pre-treatment
c. Oestrogen pre-treatment
d. GnRH antagonist pre-treatment
e. Testosterone and dehydroepiandrosterone (DHEA)
2. Protocols for controlled ovarian stimulation
a. Conventional stimulation
b. Mild stimulation
c. Modified natural cycle
3. Regimens for final oocyte maturation
a. hCG triggering
b. GnRH agonist triggering
c. Dual trigger
4. Different Luteal phase support agent
a. Progesterone and dydrogesterone
c. Other alternatives: GnRH agonists, hCG, and LH supplementation
d. Routes of administration
Keywords: IVF, ICSI, oocytes, ovarian stimulation, gonadotropins, live birth rates
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