Oxygen has been the cornerstone of medical treatment for decades, but also one of the most overused and abused remedies. Maintaining proper homeostasis between oxygen demand and delivery is critical. In clinical practice, the administration of oxygen has become an established issue although the evidence in favor of this practice is rather uncertain. Balanced oxygen administration in critically-ill patients is one of the critical issues in daily clinical setting.
Recent trials in different clinical settings have shown that high doses of oxygen have a negative effect on the outcome of patients, whereas other studies have not shown potential negative effects. Hence, a great debate has opened on the necessity to administer high dosages of oxygen in the critically-ill patient, post-operated or with recent cardiac arrest etc. Starting from the basic mechanisms of oxygen to reach the different clinical applications, an understanding of the usefulness or uselessness of oxygen is necessary.
In this Research Topic, several issues related to oxygen therapy in critically ill patients and/or in the operating room will be discussed. In particular main topics will be as follow:
- Physiology and pathophysiology of oxygen therapy in experimental studies;
- Oxygen therapy in the peri-operative period;
- The role of oxygen on microcirculation and sepsis;
- How to manage oxygen in cardiac arrest survivors?;
- Is there a role for hyperoxia in traumatic brain injury?;
- Oxygen management in ARDS and/or ECMO;
- Hyperoxia in trauma and hemorrhage;
- What about oxygen in children?
We welcome original research, reviews, mini-reviews, perspective, opinion paper, protocols and case reports for submission.
Oxygen has been the cornerstone of medical treatment for decades, but also one of the most overused and abused remedies. Maintaining proper homeostasis between oxygen demand and delivery is critical. In clinical practice, the administration of oxygen has become an established issue although the evidence in favor of this practice is rather uncertain. Balanced oxygen administration in critically-ill patients is one of the critical issues in daily clinical setting.
Recent trials in different clinical settings have shown that high doses of oxygen have a negative effect on the outcome of patients, whereas other studies have not shown potential negative effects. Hence, a great debate has opened on the necessity to administer high dosages of oxygen in the critically-ill patient, post-operated or with recent cardiac arrest etc. Starting from the basic mechanisms of oxygen to reach the different clinical applications, an understanding of the usefulness or uselessness of oxygen is necessary.
In this Research Topic, several issues related to oxygen therapy in critically ill patients and/or in the operating room will be discussed. In particular main topics will be as follow:
- Physiology and pathophysiology of oxygen therapy in experimental studies;
- Oxygen therapy in the peri-operative period;
- The role of oxygen on microcirculation and sepsis;
- How to manage oxygen in cardiac arrest survivors?;
- Is there a role for hyperoxia in traumatic brain injury?;
- Oxygen management in ARDS and/or ECMO;
- Hyperoxia in trauma and hemorrhage;
- What about oxygen in children?
We welcome original research, reviews, mini-reviews, perspective, opinion paper, protocols and case reports for submission.