Research Topic

Biochemical and Genetic Tools to Investigate the Underlying Mechanisms and Treatment of Sensorimotor Pathologies

About this Research Topic

Sensorimotor integration is key for essential everyday behaviors such as locomotion, feeding, or reproduction. These actions require a complex, fine-tuned integration of sensory and motor information encoded as neural impulses from the periphery and higher brain areas, via spinal cord circuitry. Structural ...

Sensorimotor integration is key for essential everyday behaviors such as locomotion, feeding, or reproduction. These actions require a complex, fine-tuned integration of sensory and motor information encoded as neural impulses from the periphery and higher brain areas, via spinal cord circuitry. Structural and functional plasticity within these circuits allows for adaptations in behavior.
However, after injury or in disease, these neural circuits are afflicted, resulting in a multitude of dysfunctions, not only in individual neurons but also by disrupting the signaling and connectivity between integrated neural circuits. As neural circuits are disrupted through trauma (e.g., spinal cord injury, peripheral nerve injury, TBI, stroke) or degeneration (e.g., amyotrophic lateral sclerosis, Parkinson’s disease, spinal muscular atrophy, Charcot-Marie-Tooth disease), the integration and transmission of sensory and motor information required to execute basic and complex functions is impaired, often leading to devastating life-changing effects. The latest advances in genome editing and biochemical engineering of cells have shed some light on the mechanisms of some of these diseases, as well as identified novel targets for treating them.
This Research Topic is devoted to the latest advances in biochemical and genetic engineering tools to investigate the underlying neuronal mechanisms in order to overcome functional deficits induced by sensorimotor pathologies.
We are interested in submissions discussing the development and application of genetic and biochemical engineering techniques in sensorimotor diseases such as those generated by trauma or neurodegeneration, such as:
• Genetic control of neuronal activity (Optogenetics, Chemogenetics)
• Intravital imaging (Calcium imaging, metabolic monitoring)
• Gene editing (CRISPR/Cas9, RNAi)
• Metabolic and biochemical engineering
• High throughput cellular characterization (CyTOF, scRNAseq, ATACseq, spatial transcriptomics)
We welcome the submission of original research articles using in vivo, in vitro, or clinical models that discuss the development or application of biochemical and genetic engineering tools to study mechanisms underlying pathophysiology or treatments of sensorimotor pathologies. We encourage the submission of original research, comprehensive or mini-reviews, methods, perspectives, and opinions that discuss advances in the application of biochemical and genetic engineering tools on sensorimotor diseases.


Keywords: Sensorimotor, Neurotrauma, Neurodegeneration, Gene Editing, Biochemical Engineering


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

22 March 2021 Manuscript
21 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

22 March 2021 Manuscript
21 April 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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