About this Research Topic
To overcome these drawbacks, some research groups proposed to use long overlapped peptides as vaccines, for which several phase II clinical trials have already shown efficacy – e.g. ISA’s HPV synthetic long peptide vaccine for cervical cancer and IMV’s survivin peptide vaccine for ovarian cancer. For convenience of industrial manufacturing (e.g easy quality control and regulation), recombinant overlapping peptides (ROP) have been also proposed as vaccines. In the light of these observations, research on antigen presentation of these innovative approaches is of key importance, and will shed new light on the development of safe and effective peptide-based vaccines.
With this Research Topic, we aim to provide a comprehensive overview on the current research on peptides vaccines, in terms of basic research, manufacturing and regulation, and clinical trials. Our goal is to improve the knowledge on this topic and to provide an answer to the many open questions in the field, such as: i) How a peptide vaccine is presented by Antigen Presenting Cells (APC)? ii) How do T cells respond to peptide vaccines? iii) How do peptide vaccines synergize with cancer therapies? iv) What is the best way of delivery for peptide vaccines and how adjuvants can help peptide vaccination?
We will welcome Original Research, Clinical Trial, Methods and Review articles addressing the following subtopics:
• Mechanisms of antigen-cross presentation for peptide vaccines
• T cell responses to peptide vaccines
• Prophylactic and/or therapeutic strategies for peptide vaccination
• Human and/or veterinary clinical trials using peptide vaccines against diseases (e.g. Viral/Cancer etc.)
• Combination studies – e.g. Immune checkpoint inhibitors + Peptide vaccines
• Methods of targeting DCs/APCs
• Peptide drug delivery systems
• Personalized Peptide Vaccines (PPV)
Dr. Jiang is founder and director of Oxford Vacmedix UK Ltd, an Oxford University spinout company. The other Topic Editors declare no conflict of interest with regards to the Research Topic theme.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.