Research Topic

Autoimmunity and the Brain: Paraneoplastic Neurological Injury and Beyond

About this Research Topic

Autoimmune neurological disorders represent a rapidly expanding – and frequently treatable – area of human disease, encompassing paraneoplastic neurological disorders, syndromes of autoimmune neurological injury occurring in patients without underlying neoplasia and, most recently, syndromes of autoimmune neurological injury arising in patients treated with immune checkpoint inhibitors. Important issues in this exciting new field include mechanisms of neuronal injury; differences in pathogenesis between disorders associated with antibodies to cell membrane antigens and those associated with antibodies to intracellular neuronal proteins; and the association of these conditions with infection or with alterations in host immune status caused by cancer immunotherapy.

This Research Topic will focus on innovative research data and clinical observations that expand upon, and in some cases, challenge existing dogma in the field of autoimmune neurology and neuroimmune responses to disease, including the interface of underlying immune dysfunction and disease.

For this Research Topic we welcome submissions of:
• Original Research
• Brief Research Report
• Opinion
• Systematic Review
• Policy and Practice Reviews
• Hypothesis and Theory
• Perspective
• Clinical Trials

On the following sub-topics:
• Paraneoplastic and Autoimmune Neurology Antibody Disease
• Encephalitis, at the Interface of Infection and Autoimmunity
• Neurologic Complications of Cancer Immunotherapy
• Neurologic Manifestations of Immune Dysfunction or Infection


Keywords: autoimmune encephalitis, antineuronal antibodies, paraneoplastic neurological syndromes, autoantibodies, immune checkpoint inhibitors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Autoimmune neurological disorders represent a rapidly expanding – and frequently treatable – area of human disease, encompassing paraneoplastic neurological disorders, syndromes of autoimmune neurological injury occurring in patients without underlying neoplasia and, most recently, syndromes of autoimmune neurological injury arising in patients treated with immune checkpoint inhibitors. Important issues in this exciting new field include mechanisms of neuronal injury; differences in pathogenesis between disorders associated with antibodies to cell membrane antigens and those associated with antibodies to intracellular neuronal proteins; and the association of these conditions with infection or with alterations in host immune status caused by cancer immunotherapy.

This Research Topic will focus on innovative research data and clinical observations that expand upon, and in some cases, challenge existing dogma in the field of autoimmune neurology and neuroimmune responses to disease, including the interface of underlying immune dysfunction and disease.

For this Research Topic we welcome submissions of:
• Original Research
• Brief Research Report
• Opinion
• Systematic Review
• Policy and Practice Reviews
• Hypothesis and Theory
• Perspective
• Clinical Trials

On the following sub-topics:
• Paraneoplastic and Autoimmune Neurology Antibody Disease
• Encephalitis, at the Interface of Infection and Autoimmunity
• Neurologic Complications of Cancer Immunotherapy
• Neurologic Manifestations of Immune Dysfunction or Infection


Keywords: autoimmune encephalitis, antineuronal antibodies, paraneoplastic neurological syndromes, autoantibodies, immune checkpoint inhibitors


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

06 April 2021 Manuscript
14 June 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

06 April 2021 Manuscript
14 June 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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