Genetics plays an important role in endocrine and metabolic diseases. Genetic variants may in rare cases be disease causing or in more frequent cases constitue risk factors for disorders. It is believed that in many cases it is the combination of several risk variants together with environmental factors that define the susceptibility of a person to develop a specific disease. Recent sequencing studies in thousands of humans, either composed of control groups or different disease groups, now provide an access to a rich source of information that help to identify risk variants. Risk variants can be either frequent or rare. Precise knowledge about the underlying mechanisms will help in the future to propose either personalized medicine or gene therapy.
During the « International Conference on Innovative Solutions: Cancer, Aging and Genetic diseases » held as Worldwide Live Remote Conference from October 27 to 30, 2020, more the 200 experts, especially from China, Kazakhstan and France - Academic, Medical, Investors and Industrial players- will discuss about the latest trends in the field of genetic diseases.
This special issue of Frontiers in Endocrinology welcomes submissions (original articles, comments, reviews, etc- see
here) of all participating labs of this International Congress that are of relevance to endocrinology in relation to genetic diseases. Contribution from other labs are also welcome.
Potential contributions are invited in, but not limited to, the following fields:
· Functional consequences of genetic variants on protein expression, structure, functional properties etc.
· Cellular consequences of genetic variants
· Animal models of genetic endocrine and metabolic diseases
· Clinical aspects of genetic endocrine and metabolic diseases
· Epidemiological aspects in genetic endocrine and metabolic diseases
· Genetics-based personalized medicine including pharmacological approaches, pre- and probiotic treatments, gene therapy.
Both monogenic and polygenic diseases involving disease causing variants and susceptibility genetic factors will be considered.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
