Research Topic

Advances in Pathogenesis, Etiology, and Therapies for Ankylosing Spondylitis

About this Research Topic

As the prototype of spondyloarthritis, ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the spine and sacroiliac joints. In China, the prevalence of AS is 0.25% - 0.45%. AS can be attributed to both hereditary and environmental factors. 20% - 40% of AS patients reported family history of AS, suggesting the pivotal role of genetic factors in the pathogenesis of AS. Researchers have found a strong association between HLA-B27 and a perpetual activation of both the innate and the adaptive immune systems, in particular of the IL-23/IL-17 axis and Th1 effector T-cell lineage with the overproduction of tumor necrosis factor-α (TNF-α). Humans and animal studies have also suggested the important role of T-cell mediated immune regulation in AS susceptibility. However, the precise etiology of AS remains poorly studied and merits further investigations.

Rapid progress in immunology and genetics have not only revealed the role of innate and adaptive immune cells in the triggering, initiation, development, and regulation of AS, but also shed light on mechanisms associated with resistance to AS therapy. This Research Topic aims at bringing together recent advances on the pathogenesis of AS to provide a theoretical basis for the development of new diagnostic methods, therapeutic modalities, and cell therapy technologies. Imaging and omics studies screening novel biomarkers in clinical practice predicting response to AS therapeutics (such as targeted IL-17 inhibitors) are also welcome. We welcome submissions of Original Research, Reviews, Mini-reviews, covering but not limited to, the following topics:

1. Innate and adaptive immune responses in AS
2. The relationship between susceptibility genes (e.g. ANO6) and bone metabolism/immune regulation
3. Genetic variations associated with AS and major immune signaling pathways involved in AS identified by -omics studies
4. HLA-B27 subtypes involved in immune regulation of AS
5. Novel therapeutic strategies of AS targeting immune cells


Keywords: Ankylosing Spondylitis, immune response, immune regulation, susceptibility genes, therapeutic strategies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

As the prototype of spondyloarthritis, ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the spine and sacroiliac joints. In China, the prevalence of AS is 0.25% - 0.45%. AS can be attributed to both hereditary and environmental factors. 20% - 40% of AS patients reported family history of AS, suggesting the pivotal role of genetic factors in the pathogenesis of AS. Researchers have found a strong association between HLA-B27 and a perpetual activation of both the innate and the adaptive immune systems, in particular of the IL-23/IL-17 axis and Th1 effector T-cell lineage with the overproduction of tumor necrosis factor-α (TNF-α). Humans and animal studies have also suggested the important role of T-cell mediated immune regulation in AS susceptibility. However, the precise etiology of AS remains poorly studied and merits further investigations.

Rapid progress in immunology and genetics have not only revealed the role of innate and adaptive immune cells in the triggering, initiation, development, and regulation of AS, but also shed light on mechanisms associated with resistance to AS therapy. This Research Topic aims at bringing together recent advances on the pathogenesis of AS to provide a theoretical basis for the development of new diagnostic methods, therapeutic modalities, and cell therapy technologies. Imaging and omics studies screening novel biomarkers in clinical practice predicting response to AS therapeutics (such as targeted IL-17 inhibitors) are also welcome. We welcome submissions of Original Research, Reviews, Mini-reviews, covering but not limited to, the following topics:

1. Innate and adaptive immune responses in AS
2. The relationship between susceptibility genes (e.g. ANO6) and bone metabolism/immune regulation
3. Genetic variations associated with AS and major immune signaling pathways involved in AS identified by -omics studies
4. HLA-B27 subtypes involved in immune regulation of AS
5. Novel therapeutic strategies of AS targeting immune cells


Keywords: Ankylosing Spondylitis, immune response, immune regulation, susceptibility genes, therapeutic strategies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

27 December 2020 Abstract
26 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

27 December 2020 Abstract
26 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..