Structural and computational glycobiology: immunity and infection

90.1K

views

31

authors

10

articles

Editorial

14 July 2015

Editorial: Structural and Computational Glycobiology – Immunity and Infection

Mark Agostino

and

Elizabeth Yuriev

2,681 views

0 citations

Editors

2

Elizabeth Yuriev

Monash University

Curtin University

Impact

About

Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on the structural and computational approaches to understanding of carbohydrate recognition by proteins involved in immunity and infection, particularly lectins, antibodies, cytokines and glycosyltransferases. Submissions on structural characterization (NMR and X-ray crystallography), computational method development, carbohydrate-based drug and vaccine design, carbohydrate mimicry and glycan array screening are welcomed.

Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on the structural and computational approaches to understanding of carbohydrate recognition by proteins involved in immunity and infection, particularly lectins, antibodies, cytokines and glycosyltransferases. Submissions on structural characterization (NMR and X-ray crystallography), computational method development, carbohydrate-based drug and vaccine design, carbohydrate mimicry and glycan array screening are welcomed.

Download ebook

Share

Editors

Elizabeth Yuriev

Monash University

Curtin University

Impact

90,082 Total views

66,173 Article views

19,936 Article downloads

3,973 Topic views

Published In

Journal Thumbnail

Frontiers in Immunology

Vaccines and Molecular Therapeutics

Journal Thumbnail

Frontiers in Public Health

Vaccines and Molecular Therapeutics

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic