About this Research Topic
Integrative Approaches to the Molecular Physiology of Inflammation
Inflammation is the generic name given to a number of complex biological processes related to the organismal response to a disparate set of stimuli (most of them harmful or pathogenic), either intrinsic (DNA damage, metabolic deregulation, etc.) or extrinsic (pathogens, irritants, etc.) in nature. Such processes are commonly related to a protective reaction to disease related events which involve immune response, vascularization, and cellular signaling among many other features. Recent years have witnessed an increased interest in the study of inflammation, since it was discovered that inflammatory processes are associated with a growing number of pathologies, many of which had not been previously classified as “inflammatory”.
Complex chronic diseases such as cancer, diabetes, or even Alzheimer's or Parkinson's have recently been discovered to be strongly associated with inflammatory responses. Other maladies such as cardiovascular, rheumatic and autoimmune diseases have been traditionally studied from the standpoint of inflammation. Processes such as the ones leading to aging and fragility or even hormone dysfunctions are also starting to be related to inflammatory responses.
For the above reasons, the integrated study of the physiology of inflammation and the molecular pathways associated with it, is an important goal in contemporary biomedical science. The aim of this Research Topic is hence to gather contributions from the many different fields and approaches to the physiology and the molecular origins of inflammation; particularly those that may be involved in the development and evolution of diseased phenotypes. By presenting them together we want to cooperate to unveil the commonalities and differences that so many of these phenomena have, particularly in relation to their molecular origins as well as to any issues that may enlighten prognostics, diagnostics and therapeutic decisions.
Topics may include (but are not restricted to) Inflammatory pathways in cardiovascular diseases, inflammation in cancer, pathway and network approaches to inflammation, immunity and disease, inflammation and metabolic deregulation, physiology of inflammation, pharmacology of anti-inflammatory drugs, etc.
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