The Cell Types of Fibrosis

239.3K

views

61

authors

17

articles

Editorial

22 January 2016

Editorial: The Cell Types of Fibrosis

Lynne A. Murray

6,188 views

6 citations

Editors

1

Lynne Anne Murray

AstraZeneca (United Kingdom)

Impact

About

I would like to compile a Research Topic on the key cell types involved in fibrosis. Fibrosis is a hot area of pre-clinical research as there are no known anti-fibrotics available to patients and fibrosis is a symptoms of almost every chronic disease. There are common pathways of fibrosis between organs such as activated fibroblast and myofibroblasts, pro-fibrotic macrophages and circulating collagen producing cells. Therefore this research article will assimilate the current state of knowledge in fibrotic tissue remodeling and how key cell types promote and maintain excess scar tissue, which ultimately results in tissue stiffening and loss of function. A large body of work is being done in lung fibrosis, in particular idiopathic pulmonary fibrosis. Therefore the first few articles will focus on cell types involved in cell types in the lung. Then subsequent articles will focus on tissue-specific cells and how they affect disease, for example, hepatic stellate cells and NASH/ Hepatitis, renal pericytes and diabetic nephropathy and chronic kidney disease, cardiac myocytes and post-MI fibrosis. All of the cell types listed below have intimate links with the immune response and this is changed in patients with fibrotic diseases.

I would like to compile a Research Topic on the key cell types involved in fibrosis. Fibrosis is a hot area of pre-clinical research as there are no known anti-fibrotics available to patients and fibrosis is a symptoms of almost every chronic disease. There are common pathways of fibrosis between organs such as activated fibroblast and myofibroblasts, pro-fibrotic macrophages and circulating collagen producing cells. Therefore this research article will assimilate the current state of knowledge in fibrotic tissue remodeling and how key cell types promote and maintain excess scar tissue, which ultimately results in tissue stiffening and loss of function. A large body of work is being done in lung fibrosis, in particular idiopathic pulmonary fibrosis. Therefore the first few articles will focus on cell types involved in cell types in the lung. Then subsequent articles will focus on tissue-specific cells and how they affect disease, for example, hepatic stellate cells and NASH/ Hepatitis, renal pericytes and diabetic nephropathy and chronic kidney disease, cardiac myocytes and post-MI fibrosis. All of the cell types listed below have intimate links with the immune response and this is changed in patients with fibrotic diseases.

Share

Editors

Lynne Anne Murray

AstraZeneca (United Kingdom)

Impact

239,295 Total views

187,576 Article views

47,012 Article downloads

4,707 Topic views

Published In

Journal Thumbnail

Frontiers in Pharmacology

Inflammation Pharmacology

Journal Thumbnail

Frontiers in Immunology

Inflammation Pharmacology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic