Research Topic

Traumatic Brain Injury and Neurodegeneration: Bridging the Gap

About this Research Topic

Traumatic brain injury (TBI) is a devastating neurological disorder sharing certain neuropathological markers with neurodegenerative diseases, mainly Alzheimer’s disease, despite having a distinct etiology and history. A clear biological link between TBI and AD pathology is implied by their overlapping neuropathological features, which include extracellular deposition of A plaques, intracellular aggregation of tau protein as neurofibrillary tangles, marked activation of microglia , and production of inflammatory cytokines. The initial head impact evokes an innate immune response characterized by the release of inflammatory mediators from microglia which may contribute to secondary damage and neuronal loss. How these biological processes interact after a TBI and lead to neurodegeneration is unclear. The temporal time-course of the expression of these features is also poorly documented. Neuroimaging presents an opportunity to learn more about the evolution and clinicopathological characteristics of brain trauma-induced dementia. Furthermore, the understanding of the underlying mechanisms after TBI will allow for a more thorough interpretation of changes seen on neuroimaging methods.

The literature in the past decade has been overwhelmed with studies debating the existence of a link between traumatic brain injury and Alzheimer’s or non-Alzheimer’s degenerative diseases. While a number of studies have shown a link with Alzheimer’s, other studies have shown a relationship with non-typical Alzheimer’s disease or Parkinson’s disease. This Research Topic aims to eradicate this dilemma by bringing together multimodality data, including longitudinal, preclinical and postmortem studies for an evidence-based approach to the real relationship between traumatic brain injury and neurodegenerative diseases.

The Research Topic aims to shed more clarification on whether TBI-induced processes in the brain are linked with long-term development of dementia and neurodegenerative diseases. The topic will include:
- Longitudinal progression of brain changes following traumatic brain injury.
- Neuroimaging and machine learning approaches to predict the link with dementias
- Preclinical and postmortem studies of traumatic brain injury.
- Repetitive trauma and chronic traumatic encephalopathy


Keywords: Traumatic brain injury, Neuroimaging, Neuroinflammation, Alzheimers, Neurofibrillary tau tangles, Amyloid plaques


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Traumatic brain injury (TBI) is a devastating neurological disorder sharing certain neuropathological markers with neurodegenerative diseases, mainly Alzheimer’s disease, despite having a distinct etiology and history. A clear biological link between TBI and AD pathology is implied by their overlapping neuropathological features, which include extracellular deposition of A plaques, intracellular aggregation of tau protein as neurofibrillary tangles, marked activation of microglia , and production of inflammatory cytokines. The initial head impact evokes an innate immune response characterized by the release of inflammatory mediators from microglia which may contribute to secondary damage and neuronal loss. How these biological processes interact after a TBI and lead to neurodegeneration is unclear. The temporal time-course of the expression of these features is also poorly documented. Neuroimaging presents an opportunity to learn more about the evolution and clinicopathological characteristics of brain trauma-induced dementia. Furthermore, the understanding of the underlying mechanisms after TBI will allow for a more thorough interpretation of changes seen on neuroimaging methods.

The literature in the past decade has been overwhelmed with studies debating the existence of a link between traumatic brain injury and Alzheimer’s or non-Alzheimer’s degenerative diseases. While a number of studies have shown a link with Alzheimer’s, other studies have shown a relationship with non-typical Alzheimer’s disease or Parkinson’s disease. This Research Topic aims to eradicate this dilemma by bringing together multimodality data, including longitudinal, preclinical and postmortem studies for an evidence-based approach to the real relationship between traumatic brain injury and neurodegenerative diseases.

The Research Topic aims to shed more clarification on whether TBI-induced processes in the brain are linked with long-term development of dementia and neurodegenerative diseases. The topic will include:
- Longitudinal progression of brain changes following traumatic brain injury.
- Neuroimaging and machine learning approaches to predict the link with dementias
- Preclinical and postmortem studies of traumatic brain injury.
- Repetitive trauma and chronic traumatic encephalopathy


Keywords: Traumatic brain injury, Neuroimaging, Neuroinflammation, Alzheimers, Neurofibrillary tau tangles, Amyloid plaques


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

05 February 2021 Abstract
05 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

05 February 2021 Abstract
05 August 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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