Research Topic

Precision Medicine in Obstructive Sleep Apnea (OSA)

About this Research Topic

Obstructive Sleep Apnea (OSA) is an underestimated sleep disordered breathing (SDB), affecting more than 900 million people worldwide, encompassing 50% of patients between 30 and 69 years of age, and represents a demonstrated risk factor for cardio- and cerebrovascular diseases, and motor vehicle accidents. First-line therapy for OSA includes positive airway pressure (PAP), but options for a precision based approach for patient centered care have to be considered. Such therapies include mandibular advancement devices (MAD), upper airway (UA), nasal, and skeletal surgery, hypoglossal nerve stimulation, positional therapy, weight loss, myofunctional therapy and drug therapy. All these OSA treatment options collect a success and failure rate, reported by the specific literature.

The aim of this Research Topic is to develop, through the critical analysis of updated literature along with the experience collected in several renowned sleep centers worldwide, a protocol that should allow us to apply the main concepts of precision medicine to OSA, which customizes the several treatment options to a single patient, suggesting that only a multidisciplinary – multimodal and upfront selection approach for OSA diagnosis and treatment could achieve the best therapeutic outcome, overcoming “the one-fits all” model, that is currently not acceptable in OSA clinical approach.

Here are some topics suggestions within the scope of applications of precision medicine to obstructive sleep apnea syndrome (OSA):

• OSA pathophysiology: from physiological traits to PALM classification.
• The role of awake clinical evaluation vs drug-induced sleep endoscopy vs. upper airway assessment during natural sleep in physiological traits identification
• CPAP therapy and multimodal OSA treatments
• UA surgery, skeletal surgery, MAD and hypoglossal stimulation: a customized approach
• The frontiers of OSA treatment: drug and myofunctional treatment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Obstructive Sleep Apnea (OSA) is an underestimated sleep disordered breathing (SDB), affecting more than 900 million people worldwide, encompassing 50% of patients between 30 and 69 years of age, and represents a demonstrated risk factor for cardio- and cerebrovascular diseases, and motor vehicle accidents. First-line therapy for OSA includes positive airway pressure (PAP), but options for a precision based approach for patient centered care have to be considered. Such therapies include mandibular advancement devices (MAD), upper airway (UA), nasal, and skeletal surgery, hypoglossal nerve stimulation, positional therapy, weight loss, myofunctional therapy and drug therapy. All these OSA treatment options collect a success and failure rate, reported by the specific literature.

The aim of this Research Topic is to develop, through the critical analysis of updated literature along with the experience collected in several renowned sleep centers worldwide, a protocol that should allow us to apply the main concepts of precision medicine to OSA, which customizes the several treatment options to a single patient, suggesting that only a multidisciplinary – multimodal and upfront selection approach for OSA diagnosis and treatment could achieve the best therapeutic outcome, overcoming “the one-fits all” model, that is currently not acceptable in OSA clinical approach.

Here are some topics suggestions within the scope of applications of precision medicine to obstructive sleep apnea syndrome (OSA):

• OSA pathophysiology: from physiological traits to PALM classification.
• The role of awake clinical evaluation vs drug-induced sleep endoscopy vs. upper airway assessment during natural sleep in physiological traits identification
• CPAP therapy and multimodal OSA treatments
• UA surgery, skeletal surgery, MAD and hypoglossal stimulation: a customized approach
• The frontiers of OSA treatment: drug and myofunctional treatment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

01 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

01 September 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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