About this Research Topic
Obstructive Sleep Apnea (OSA) is an underestimated sleep disordered breathing (SDB), affecting more than 900 million people worldwide, encompassing 50% of patients between 30 and 69 years of age, and represents a demonstrated risk factor for cardio- and cerebrovascular diseases, and motor vehicle accidents. First-line therapy for OSA includes positive airway pressure (PAP), but options for a precision based approach for patient centered care have to be considered. Such therapies include mandibular advancement devices (MAD), upper airway (UA), nasal, and skeletal surgery, hypoglossal nerve stimulation, positional therapy, weight loss, myofunctional therapy and drug therapy. All these OSA treatment options collect a success and failure rate, reported by the specific literature.
The aim of this Research Topic is to develop, through the critical analysis of updated literature along with the experience collected in several renowned sleep centers worldwide, a protocol that should allow us to apply the main concepts of precision medicine to OSA, which customizes the several treatment options to a single patient, suggesting that only a multidisciplinary – multimodal and upfront selection approach for OSA diagnosis and treatment could achieve the best therapeutic outcome, overcoming “the one-fits all” model, that is currently not acceptable in OSA clinical approach.
Here are some topics suggestions within the scope of applications of precision medicine to obstructive sleep apnea syndrome (OSA):
• OSA pathophysiology: from physiological traits to PALM classification.
• The role of awake clinical evaluation vs drug-induced sleep endoscopy vs. upper airway assessment during natural sleep in physiological traits identification
• CPAP therapy and multimodal OSA treatments
• UA surgery, skeletal surgery, MAD and hypoglossal stimulation: a customized approach
• The frontiers of OSA treatment: drug and myofunctional treatment
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