About this Research Topic
Fighting infections requires an ever-changing immune system in which timely gene expression is controlled both at the transcriptional and post-transcriptional level. Nowadays there is a good understanding of how transcription factor networks control the immune system but recent evidence shows that post-transcriptional regulation by RNA binding proteins (RBPs) is equally important for both development and activation of the immune system.
RNA binding proteins control RNA editing, splicing location, stability, and translation. RBPs such as Zfp36l1 and Zfp36l2 regulate key aspects of immune cell metabolism, development, and differentiation commonly by binding and controlling the expression of set of genes. Others such as Regnase-1 and Roquin play important roles in the immune system by controlling cell homeostasis, cell proliferation, activation and differentiation. RBP expression, function and subcellular location are regulated at the post-translational level and coupled to cellular signalling networks that sense danger allowing timely control of cytokine expression during inflammation and disease. RBPs differentially bind to the same mRNA targets having opposing functions. Binding of HuR with the TNF mRNA promotes it’s stability and translation whereas TTP binding promotes mRNA destabilization and decay.
In this Research Topic, we welcome the submission of Original Research, Review, Mini-Review, Method and Opinion articles that feature recent advances in our understanding of how RNA binding proteins control gene expression during immune system development, dysfunction and response to pathogens. The aim of this Research Topic is to gather a collection of articles that address, but are not limited to, the following topics:
• Regulation of immune system development by RNA binding proteins
• Contribution of RNA binding proteins to the initiation, propagation and resolution of immune responses and inflammation
• Modulation of RNA binding protein function in the immune system
• Drug targeting RNA binding proteins to modulate immune system function
• Models and methods to study RNA binding proteins function in immune cells
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). Dr. Osamu Takeuchi is a committee member for the IUIS Publications Committee.
Keywords: RNA, RNA binding proteins (RBP), Post-transcriptional regulation, inflammation, infection, immune system development, autoimmunity
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