Patients with Chronic kidney diseases (CKD) present a retention and consequent accumulation of uremic toxins. These toxins degrade basic biological functions disrupting homeostasis, causing metabolic changes and the onset of inflammatory conditions. Among these toxins, Indoxyl Sulfate and P-Cresyl Sulfate stand out, which have low molecular weight and are associated with serum proteins, making it difficult to filter through the dialysis barrier.
The kidneys and heart have a close relationship and share several functions in order to maintain the organism's homeostasis. The injury caused by renal dysfunctions to the heart or vice versa are treated in the literature as Cardiorenal Syndrome. Although it is known that kidney injuries can cause cardiac dysfunction as presented in SCR types 3 and 4, the mechanisms that lead to an increase in cardiovascular complications among patients (CKD) due to the retention of uremic toxins such as Indoxyl sulfate or P-Cresyl Sulfate, are not completely understood.
Studies related to retention of uremic compounds and their potential deleterious effects on the heart, whether in morphology or function, are still scarce and require further research and investigation. Thus, the present Research Topic aims to group several studies regarding research on uremic compounds and the development of cardiorenal syndrome.
This article collection aims to gather original scientific studies or reviews that may contribute to the theme related to the role of uremic compounds in renal and cardiac landings observed in cardiorenal syndrome.
Patients with Chronic kidney diseases (CKD) present a retention and consequent accumulation of uremic toxins. These toxins degrade basic biological functions disrupting homeostasis, causing metabolic changes and the onset of inflammatory conditions. Among these toxins, Indoxyl Sulfate and P-Cresyl Sulfate stand out, which have low molecular weight and are associated with serum proteins, making it difficult to filter through the dialysis barrier.
The kidneys and heart have a close relationship and share several functions in order to maintain the organism's homeostasis. The injury caused by renal dysfunctions to the heart or vice versa are treated in the literature as Cardiorenal Syndrome. Although it is known that kidney injuries can cause cardiac dysfunction as presented in SCR types 3 and 4, the mechanisms that lead to an increase in cardiovascular complications among patients (CKD) due to the retention of uremic toxins such as Indoxyl sulfate or P-Cresyl Sulfate, are not completely understood.
Studies related to retention of uremic compounds and their potential deleterious effects on the heart, whether in morphology or function, are still scarce and require further research and investigation. Thus, the present Research Topic aims to group several studies regarding research on uremic compounds and the development of cardiorenal syndrome.
This article collection aims to gather original scientific studies or reviews that may contribute to the theme related to the role of uremic compounds in renal and cardiac landings observed in cardiorenal syndrome.
