About this Research Topic
The Research Topic of this collection is intended to highlight the basic and applied science and clinical trials behind the idea of developing immune-based strategies of the treatment of viral infections.
We welcome the submission of Mini Reviews, Reviews, Original Research, Clinical Trial and Methods articles covering, but not limited to, the following sub-topics:
• Mediators of inflammation as targets for the co-adjuvant treatment of viral infections.
• Clinical studies defining expression of mediators or genes associated with disease severity during viral infections and that may be amenable for novel drug development.
• Pathway mapping: elucidation of key immunological events to target viral infections using in vitro and ex vivo approaches.
o Viruses with cellular-factor immune dysregulation.
o Pathway mapping strategies to identify targets for immunomodulatory intervention across viral infections.
o Repurposed drug candidates
• “Cross-talk crossover”: Jak 1/2 inhibitors and repurposing across multiple indications:
o Jak 1/2 inhibitors: From arthritis to HIV to COVID-19: hopscotch from arthritis to efficacy in HIV human trials, to Emergency Use FDA Authorization for COVID-19.
o Insight from Jak 1/2 crossover: could other viruses be targeted beyond HIV and SARS-CoV-2?
• Platform paradigm: What can we learn from modulating the immune response for one virus that can be applied to successful targeting of other viruses?
o Common hallmarks of immune dysregulation across viruses that could be targeted.
o Cytokine storm syndrome across viruses-targeted immunomodulation versus global blocking strategies: what have we learned, where can we go next?
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.