Research Topic

Interactions of Pentraxins and Complement in Infection, Inflammation, and Cancer

About this Research Topic

Complement is an important innate immune defense machinery and plays crucial roles in infection and inflammation. Today, the complement is not only a driver of innate immunity, its functions even extend to additional physiological and/or pathophysiological roles in immune surveillance and homeostasis. The

...

Complement is an important innate immune defense machinery and plays crucial roles in infection and inflammation. Today, the complement is not only a driver of innate immunity, its functions even extend to additional physiological and/or pathophysiological roles in immune surveillance and homeostasis. The complement exerts its functions through effective rules of activation and regulation under precise control of balance. However, if dysregulated, the complement often leads to pathophysiological situations.


Pentraxins are a superfamily of pattern recognition molecules characterized by a cyclic multimeric structure and a conserved pentraxin signature. Based on the primary structure of the subunit, the pentraxins are defined as short pentraxins (C-reactive protein, CRP; serum-amyloid P component, SAP) or long pentraxins (pentraxin 3, PTX3; pentraxin 4, PTX4; neuronal pentraxin 1, NP1; neuronal pentraxin 2, NP2; neuronal pentraxin receptor, NPR). The pentraxins are involved in both complement activation and regulation, thus diversify the immune effector functions and further restrict overwhelming inflammation.


The complement system is a double-edged sword, playing a key role in the elimination of danger signals and hostile intruders, but also being responsible for immunopathology when massively activated or improperly controlled. Pentraxins are involved in both complement activation and regulation via crosstalk with major complement initiating molecules as well as complement regulators. The crosstalk events between the pentraxins and the PRMs involved in complement activation synergize their roles in immunosurveillance, anti-microbial immune responses, and immunologic homeostasis. However, these cooperative events may also lead to immunopathogenicity in infection and inflammation if activated inappropriately. Pentraxins-mediated complement activation and regulation may also influence and thus contribute to chronic inflammation, which likely constructs a microenvironment for initiation and development of complement-mediated pathology. The beneficial and pathogenic side of the potential functional roles of pentraxins and their involvement in complement activation and regulation need to be further explored. Whether it is involved in potent inducers of immunopathology during infection and inflammation and how it exacerbates disease severity are also intriguing unanswered questions. 


This Research Topic aims to gain an insight into the functional roles of the pentraxins in infection and regulation of inflammatory responses with a focus on the interaction with the complement system. We welcome the submission of manuscripts including Original Research, Review, Mini-Review, Perspective, Commentary, and Opinion articles types that cover, but are not limited to, the following topics:


1) Biochemical interactions between pentraxins and complement 

2) Role of the pentraxins in complement activation, regulation, and crosstalk

3) Interaction of pentraxins and complement in infections

4) Interaction of pentraxins and complement in vascular pathology

5) Interaction of pentraxins and complement in cancer




Dr. Garlanda is the inventor of the patent (EP20182181) on pentraxin-3 . The other Topic Editors declare no conflict of interest with regards to the Research Topic theme.


Keywords: Pentraxins, Complement, Complement activation, Complement regulation, Pattern-recognition molecules, Pattern-recognition receptors, PRRs, Infection, inflammation, cancer


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

30 July 2021 Manuscript
30 September 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

30 July 2021 Manuscript
30 September 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..