Aging clocks in longevity medicine: from functional to multi-omics

Longevity medicine is on the rise thanks to recent discoveries around the mechanisms and biomarkers of aging. Aging biomarkers or “clocks” can estimate an organism's biological age, which is the age of its molecules, cells, tissues, and systems. Aging clocks can provide valuable tools to assess health states and evaluate the effectiveness of anti-aging interventions. They are commonly divided into three main categories: molecular or -omics clocks (e. g. epigenomics, proteomics, metabolomics, transcriptomics, multi-omics, telomere length), functional clocks (e. g. hematological), and digital clocks (e. g. face clocks).

The goal of this research topic is to understand the mechanistic aspects of aging clocks and explore their clinical applications. Aging clocks are composite measures of biological age that capture different aging processes (e. g. cellular senescence) and consequences (e. g. mortality risk) of aging. A better understanding of the biological signals captured by aging clocks will advance the way we understand and measure the causes and consequences of aging and intervene to reverse them.

· Omics clocks and their integration with functional and digital clocks (e. g. epigenomics, proteomics, metabolomics, transcriptomics, multi-omics, blood markers, face clocks, psychological clocks, etc.)
· Anti-aging interventions using aging clocks (e.g. diet, lifestyle, physical activity, geroprotectors)
· Mechanistical studies of aging clocks

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