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About this Research Topic

Manuscript Submission Deadline 15 January 2023

Chronic kidney disease (CKD) leads to irreversible kidney damage that progresses to End Stage Kidney Disease (ESKD) and is estimated to effect 37 million people in the US. This presents a serious public health problem effecting ~15% of the adult population worldwide. While available treatments for CKD only ...

Chronic kidney disease (CKD) leads to irreversible kidney damage that progresses to End Stage Kidney Disease (ESKD) and is estimated to effect 37 million people in the US. This presents a serious public health problem effecting ~15% of the adult population worldwide. While available treatments for CKD only slow disease progression, there is an immense need for development of novel therapeutics to halt or reverse disease progression. Recent studies have identified Tubulopathy and Podocytopathy as major determinants of CKD progression. However, the causative role of them is still unclear. Therefore, we propose an issue to focus on these important opathies in kidney disease.

The goal of this Research Topic is to identify the role tubule and podocyte place in CKD. In fact, the complexity of the kidney does not allow us to point to a singular causative cell type, but to understand each individually and how they work in concert. We aim to increase the knowledge that these cells play in CKD. This is increasingly important as there are several ongoing clinical trials targeting these cell types for treatment. Therefore, understanding the underlying biology will significantly increase the ability to support translational medicine.

The scope of this Research Topic encompasses the role of Podocytopathies and Tubulopathies in CKD. The overall themes include understanding the role of these cell types as mediators of disease. We have chosen a topic in CKD to accommodate the different subspecialties/diseases knowledge areas within the proposed guest editor team (Focal Segmental Glomerulosclerosis, Diabetic Kidney Disease, Polycystic Kidney Diseases, Alport Syndrome, Lupus etc.). We expect that we will be able to accommodate primary research articles within this focus with the wide expertise on the co-guest editor team.

Keywords: Tubulopathy, Chronic Kidney Disease, Cytokine, Podocytopathy


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