Retinopathies including diabetic retinopathy (DR), proliferative vitreoretinopathy (PVR), macular degeneration, retinitis pigmentosa (RP) can lead to blindness without timely treatment. Since vascular endothelial growth factor (VEGF) was identified as a prominent factor for promoting vascular leakage and angiogenesis, neutralization of VEGF has become the first-line therapy for ischemic retinopathies including DR and retinal occlusions; however, novel treatments are still needed for these angiogenesis-related retinal diseases due to the fact that not all the patients with these retinopathies respond to the anti-VEGF therapy. Molecular genetics has been used not only to clarify diagnosis but also enable to treat inherited retinal diseases. For instance, recombinant adeno-associated virus (AAV) vector-based gene therapy has been approved for the treatment of RPE65-mutation-associated retinal dystrophies using Luxturna because the eye is known as an immune-privileged site. In particular, the advent of CRISPR/Cas9 genome editing technologies provides researchers and clinicians with a powerful tool for developing novel strategies to treat patients with inherited retinal dystrophies. In this Research Topic, a wide range of novel potential therapeutic approaches from gene therapy to pharmacological interventions will be solicited for submission.
This Research Topic aims at identifying novel therapeutic approaches for a variety of retinal diseases including diabetic retinopathy, retinal occlusions, retinal tear, retinal detachment, epiretinal membrane, macular hole, macular degeneration, retinitis pigmentosa. The submitted manuscripts on this research topic will provide authors with novel strategies (e.g., gene therapy, stem cell therapy, pharmacological intervention) for treating drastic retinal diseases.
We welcome submissions of Original Research, Case Reports, and Review articles focusing on retinopathies with potential novel therapeutic strategies. Topics of interest include, but is not limited to, the following aspects
- Diabetic retinopathy
- Inherited retinal diseases
- Macular degeneration
- Pathological myopia
- Retinal detachment
- Retinopathy of prematurity
Retinopathies including diabetic retinopathy (DR), proliferative vitreoretinopathy (PVR), macular degeneration, retinitis pigmentosa (RP) can lead to blindness without timely treatment. Since vascular endothelial growth factor (VEGF) was identified as a prominent factor for promoting vascular leakage and angiogenesis, neutralization of VEGF has become the first-line therapy for ischemic retinopathies including DR and retinal occlusions; however, novel treatments are still needed for these angiogenesis-related retinal diseases due to the fact that not all the patients with these retinopathies respond to the anti-VEGF therapy. Molecular genetics has been used not only to clarify diagnosis but also enable to treat inherited retinal diseases. For instance, recombinant adeno-associated virus (AAV) vector-based gene therapy has been approved for the treatment of RPE65-mutation-associated retinal dystrophies using Luxturna because the eye is known as an immune-privileged site. In particular, the advent of CRISPR/Cas9 genome editing technologies provides researchers and clinicians with a powerful tool for developing novel strategies to treat patients with inherited retinal dystrophies. In this Research Topic, a wide range of novel potential therapeutic approaches from gene therapy to pharmacological interventions will be solicited for submission.
This Research Topic aims at identifying novel therapeutic approaches for a variety of retinal diseases including diabetic retinopathy, retinal occlusions, retinal tear, retinal detachment, epiretinal membrane, macular hole, macular degeneration, retinitis pigmentosa. The submitted manuscripts on this research topic will provide authors with novel strategies (e.g., gene therapy, stem cell therapy, pharmacological intervention) for treating drastic retinal diseases.
We welcome submissions of Original Research, Case Reports, and Review articles focusing on retinopathies with potential novel therapeutic strategies. Topics of interest include, but is not limited to, the following aspects
- Diabetic retinopathy
- Inherited retinal diseases
- Macular degeneration
- Pathological myopia
- Retinal detachment
- Retinopathy of prematurity