Neuro-Humoral Control during Orthostasis in Health and Disease

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University of Texas Southwestern Medical Center

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Different from many other species, human beings spend most of their time in an upright posture on two feet. Due to gravity, about 700 to 900 ml of blood shift into the lower body during quiet standing. As a result, central blood volume decreases and this leads to a series of neural-humoral adjustments that aims to maintain the mean arterial pressure during orthostasis. Both the sympathetic nervous system and the renin-angiotensin-aldosterone system contribute importantly to the arterial pressure maintenance in upright humans. There is a growing interest in the blood pressure regulation during orthostatic stress in healthy individuals and in patient populations. This call for papers is for any aspects of the circulatory control during orthostasis in both health and disease.

Different from many other species, human beings spend most of their time in an upright posture on two feet. Due to gravity, about 700 to 900 ml of blood shift into the lower body during quiet standing. As a result, central blood volume decreases and this leads to a series of neural-humoral adjustments that aims to maintain the mean arterial pressure during orthostasis. Both the sympathetic nervous system and the renin-angiotensin-aldosterone system contribute importantly to the arterial pressure maintenance in upright humans. There is a growing interest in the blood pressure regulation during orthostatic stress in healthy individuals and in patient populations. This call for papers is for any aspects of the circulatory control during orthostasis in both health and disease.

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University of Texas Southwestern Medical Center

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Frontiers in Physiology

Integrative Physiology

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