Kisspeptins are biologically active peptides derived from the KISS1 gene and signal via the G-protein coupled kisspeptin receptor (KISS1R). Kisspeptin signaling was first discovered as a regulator of cancer metastasis and then as a potent regulator of the neuroendocrine-reproductive axis.
Rapidly emerging evidence now reveals roles for peripheral kisspeptin signaling in regulating metabolism in tumors and metabolic pathways such as in adipose, liver, and pancreas. Its effect on reproduction, acting directly via the ovary and endometrium, is also now recognized.
This Research Topic welcomes articles describing the recent advances of the roles of peripheral kisspeptin signaling in regulating cancer, glucose homeostasis, and metabolism, in addition to ovarian and endometrial function. We welcome the submission of Original Research, Review, Mini Reviews, and Perspectives articles on topics including, but not limited to the following:
• Kisspeptin signaling in regulating tumor metabolism, growth or metastasis,
• Role of miRNA in kisspeptin signaling
• Kisspeptin signaling in regulating metabolism (such as in adipose, liver, pancreas)
• Kisspeptin signaling in reproduction (such as ovary and uterus)
Kisspeptins are biologically active peptides derived from the KISS1 gene and signal via the G-protein coupled kisspeptin receptor (KISS1R). Kisspeptin signaling was first discovered as a regulator of cancer metastasis and then as a potent regulator of the neuroendocrine-reproductive axis.
Rapidly emerging evidence now reveals roles for peripheral kisspeptin signaling in regulating metabolism in tumors and metabolic pathways such as in adipose, liver, and pancreas. Its effect on reproduction, acting directly via the ovary and endometrium, is also now recognized.
This Research Topic welcomes articles describing the recent advances of the roles of peripheral kisspeptin signaling in regulating cancer, glucose homeostasis, and metabolism, in addition to ovarian and endometrial function. We welcome the submission of Original Research, Review, Mini Reviews, and Perspectives articles on topics including, but not limited to the following:
• Kisspeptin signaling in regulating tumor metabolism, growth or metastasis,
• Role of miRNA in kisspeptin signaling
• Kisspeptin signaling in regulating metabolism (such as in adipose, liver, pancreas)
• Kisspeptin signaling in reproduction (such as ovary and uterus)
