Research Topic

When Physics meets Biology; Biomechanics and Biology of Traumatic Brain Injury

  • Submission closed.

About this Research Topic

Traumatic brain injury (TBI) is a unique CNS disorder resulting from direct or indirect interactions of physical forces with the head and eventually with the brain (when physics meets biology). The physical forces, their energy level, their distribution – focal or diffuse, etc. triggering TBI are highly ...

Traumatic brain injury (TBI) is a unique CNS disorder resulting from direct or indirect interactions of physical forces with the head and eventually with the brain (when physics meets biology). The physical forces, their energy level, their distribution – focal or diffuse, etc. triggering TBI are highly complex. How the energy is transferred, what biological structures, tissues, cellular and subcellular elements are involved and how they respond to the physical events further adds to the complexity. The initial (primary) biological response to the physical components ranging from physical annihilation of tissue and cells to the (transient) upending of the highly complex, delicate and carefully maintained balances between ions and molecules across various biological barriers.
The failures of the last decades to develop effective and evidence based therapeutics in TBI are partly due to lack of high fidelity models of TBI due to our incomplete understanding of interactions between physical and biological events.
The extensive use of explosive blast as weapon or as mean of terror has been a “game changer”. Explosive blast is not only a highly complex type of physical forces but it appears that the resulting TBI is a highly complex kind of injury. The new public awareness about TBI has been further increased by reports and studies related to mild athletic or sport injuries (concussions), which are often repeated.
Our goal with launching this Research Topic is to review and summarize the most current knowledge about the physical components that cause the various forms of TBIs; in biomechanics of the brain, the various biological structures affected by physical forces, and their molecular and cellular responses to mechanical insults. Importantly, we would like to encourage presentations of ongoing original works in this Research Topic.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top