Sarcopenia is an age-related skeletal muscle atrophy syndrome. Muscle decline starts at age 30 and if not exercise, by 50 people will have lost 10 percent of their muscle mass. Most people begin to feel a decline in muscle strength as they get older. Between the ages of 60 and 70, it shrinks by about 15 percent, and after 80, it shrinks by as much as 30 percent each decade. On average, after age 40, muscle mass (good weight) loses about 5 kg every 10 years. Current studies have shown that sarcopenia caused by aging is mainly related to nutrition, exercise, related hormones, inflammation, mitochondrial abnormalities, muscle satellite cells and, autophagy, as well as genetic factors. Sarcopenia is closely related to metabolic diseases and cardiovascular diseases and is associated with increased risks of falls, fractures, disabilities, and increased rate of hospitalization and mortality in the elderly, which can increase medical, social, and economic burdens.
The purpose of this Research Topic is to improve the understanding of sarcopenia among researchers and to conduct further research on its mechanisms, harms, and interventions to reduce the occurrence of sarcopenia.
We welcome submissions of Original Research and Review articles on the following themes:
1. Review of sarcopenia and metabolic diseases (Review)
2. Pathogenesis and potential intervention targets of sarcopenia (Review)
3. Epidemiological studies on sarcopenia and associated metabolic diseases
4. Interactions between sarcopenia and metabolic diseases and their cardiovascular outcomes
5. Mechanism of muscle cell injury and apoptosis
6. Metabolic reprogramming of muscle cells
For manuscripts on sarcopenic obesity, please submit to
(Osteo)Sarcopenia & Sarcopenic ObesityFor manuscripts on epigenetic regulation of sarcopenia, please submit to
Epigenetic Regulation of the Musculoskeletal System in Health, Disease, and Aging