About this Research Topic
Tyrosine kinases (TKs) control a wide range of biological functions, including cell proliferation, differentiation and metabolism. Under normal physiologic conditions, the TK activity is tightly balanced by the activity of protein tyrosine phosphatases (PTPs). A balanced activation of TKs and PTPs is crucial to guarantee the physiological development of thymocytes as well as the functions of peripheral T-cells. Genomic and nongenomic mechanisms eliciting the aberrant activation of tyrosine kinases and/or the loss of phosphatases activities perturb the physiological development of T-cells and their controlled proliferation, thus playing a significant role in the development of T-cell malignancies, a heterogeneous group of disorders resulting from the clonal evolution of dysfunctional T-cells at various stages of development.
This Research Topic focus on understanding the mechanisms deregulating the balance between TK and PTP activities and their oncogenic consequences. This Research Topics aims at dissecting TK and PTP role in the development of mature and immature T-cell malignancies and to highlight the development of related targeted therapies in these diseases.
We welcome Original Research articles, Reviews, Mini Reviews, Case Reports, Clinical Trials and Perspectives. The following topics are of particular interest:
- Studies investigating the biological and clinical features of tyrosine kinase/phosphatase alterations in T-cell malignancies
- Reviews and mechanistic studies focusing on the physio-pathological roles of tyrosine kinases/phosphatases in T-cell malignancies
- Mechanistic studies investigating oncogenic signaling pathways resulting from de-regulated tyrosine kinases/phosphatases in T-cell malignancies
-Reviews and clinical trials evaluating specific therapies targeting TK/PTP in T-cell malignancies
Keywords: T-cell lymphomas, T-cell acute lyphoblastic leukemia, T-cell lyphoblastic lymphomas, tyrosine kinase, tyrosine phosphatases, targeted therapies
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