Research Topic

Tyrosine Kinases and Phosphatases in T- Cell Malignancies

About this Research Topic

Tyrosine kinases (TKs) control a wide range of biological functions, including cell proliferation, differentiation and metabolism. Under normal physiologic conditions, the TK activity is tightly balanced by the activity of protein tyrosine phosphatases (PTPs). A balanced activation of TKs and PTPs is crucial to guarantee the physiological development of thymocytes as well as the functions of peripheral T-cells. Genomic and nongenomic mechanisms eliciting the aberrant activation of tyrosine kinases and/or the loss of phosphatases activities perturb the physiological development of T-cells and their controlled proliferation, thus playing a significant role in the development of T-cell malignancies, a heterogeneous group of disorders resulting from the clonal evolution of dysfunctional T-cells at various stages of development.

This Research Topic focus on understanding the mechanisms deregulating the balance between TK and PTP activities and their oncogenic consequences. This Research Topics aims at dissecting TK and PTP role in the development of mature and immature T-cell malignancies and to highlight the development of related targeted therapies in these diseases.

We welcome Original Research articles, Reviews, Mini Reviews, Case Reports, Clinical Trials and Perspectives. The following topics are of particular interest:
- Studies investigating the biological and clinical features of tyrosine kinase/phosphatase alterations in T-cell malignancies
- Reviews and mechanistic studies focusing on the physio-pathological roles of tyrosine kinases/phosphatases in T-cell malignancies
- Mechanistic studies investigating oncogenic signaling pathways resulting from de-regulated tyrosine kinases/phosphatases in T-cell malignancies
-Reviews and clinical trials evaluating specific therapies targeting TK/PTP in T-cell malignancies


Keywords: T-cell lymphomas, T-cell acute lyphoblastic leukemia, T-cell lyphoblastic lymphomas, tyrosine kinase, tyrosine phosphatases, targeted therapies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Tyrosine kinases (TKs) control a wide range of biological functions, including cell proliferation, differentiation and metabolism. Under normal physiologic conditions, the TK activity is tightly balanced by the activity of protein tyrosine phosphatases (PTPs). A balanced activation of TKs and PTPs is crucial to guarantee the physiological development of thymocytes as well as the functions of peripheral T-cells. Genomic and nongenomic mechanisms eliciting the aberrant activation of tyrosine kinases and/or the loss of phosphatases activities perturb the physiological development of T-cells and their controlled proliferation, thus playing a significant role in the development of T-cell malignancies, a heterogeneous group of disorders resulting from the clonal evolution of dysfunctional T-cells at various stages of development.

This Research Topic focus on understanding the mechanisms deregulating the balance between TK and PTP activities and their oncogenic consequences. This Research Topics aims at dissecting TK and PTP role in the development of mature and immature T-cell malignancies and to highlight the development of related targeted therapies in these diseases.

We welcome Original Research articles, Reviews, Mini Reviews, Case Reports, Clinical Trials and Perspectives. The following topics are of particular interest:
- Studies investigating the biological and clinical features of tyrosine kinase/phosphatase alterations in T-cell malignancies
- Reviews and mechanistic studies focusing on the physio-pathological roles of tyrosine kinases/phosphatases in T-cell malignancies
- Mechanistic studies investigating oncogenic signaling pathways resulting from de-regulated tyrosine kinases/phosphatases in T-cell malignancies
-Reviews and clinical trials evaluating specific therapies targeting TK/PTP in T-cell malignancies


Keywords: T-cell lymphomas, T-cell acute lyphoblastic leukemia, T-cell lyphoblastic lymphomas, tyrosine kinase, tyrosine phosphatases, targeted therapies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

20 June 2021 Abstract
18 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

20 June 2021 Abstract
18 October 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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