About this Research Topic
The purpose of this topic is to outline the basic principles of PET-CT imaging, with a
focus on 18F-FDG PET-CT and PET-CT imaging by using other radiotracers. Basic physiology, variant imaging appearances and potential pitfalls of image interpretation are presented within the context of common use cases of PET technology in patients with cancers and other pathologies, benign and malignant.
Increased glucose uptake in tumour cells is a result of increased anaerobic glycolysis, known as the Warburg effect. Cancer cells express an increased number of specific glucose transporter proteins compared to normal tissue cells. Diagnosis of malignant tumours is therefore a major indication for 18F-FDG PET–CT imaging.
Incidental findings and technical artefacts are common on 18F-FDG PET-CT imaging. Comprehensive knowledge of variant physiological biodistribution and potential pitfalls of image interpretation are vital to maximise diagnostic accuracy. Patient outcomes can also be improved with appropriate complementary use of structural imaging with either CT, MR or ultrasound in a number of malignant pathologies.
• Normal biodistribution of FDG
• Patients preparation, image acquisition
• Normal anatomy
• Normal (physiological) variants
• Attenuation correction Artifacts
• Pitfalls, false positives and false negatives
Keywords: imaging, pet, spect, CT, pitfalls, artifacts
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