Endogenous brain repair is a complicated and important process for restoring brain function after cerebrovascular disease. Blood components, pericytes, microglia, astroglia, perivascular space and other factors are likely to play important roles in endogenous brain repair. After brain injury, unfortunately, endogenous neurogenesis and neuroregeneration are insufficient for brain repair and brain function restoration. Understanding the mechanisms of endogenous brain repair, as well as their roles in reducing and alleviating secondary brain injury could lead to novel therapeutical approaches for promoting brain repair and improving brain function. Over the past decades, many molecular and cellular mechanisms of endogenous brain repair`, such as anti-inflammation, anti-oxidation, and anti-apoptosis, have been extensively studied. However, other mechanisms, such as waste clearance, still need to be further investigated.
This Research Topic aims to gain a better understanding of the mechanisms of endogenous brain repair after acute or chronic brain injury in cerebrovascular diseases. We hope that this Research Topic will provide new insights into the development of novel therapeutic approaches for treating brain injuries and restoring brain function in a variety of cerebrovascular diseases.
We welcome all Original Research articles and Reviews that focus on, but not limited to, the following topics:
-The mechanisms of endogenous brain repair in cerebrovascular diseases, such as the role of scavenger receptors, glial activation, glymphatic system, phagocytosis, autophagy, and their regulatory pathways in the brain repair processes.
- The common and different mechanism of endogenous brain repair among different cerebrovascular diseases, including stroke (acute ischemic or hemorrhagic accident), chronic cerebrovascular diseases (cerebral small vessel diseases, amyloid angiopathy, central nervous system vasculitis, leucoaraiosis).
- The translational research for treating brain injury in cerebrovascular diseases, such as identify novel therapeutical targets that could directly stimulate endogenous neurogenesis and neuroregeneration for brain repair.
- The endogenous repair mechanisms for treating cognitive impairments in cerebrovascular diseases.
Endogenous brain repair is a complicated and important process for restoring brain function after cerebrovascular disease. Blood components, pericytes, microglia, astroglia, perivascular space and other factors are likely to play important roles in endogenous brain repair. After brain injury, unfortunately, endogenous neurogenesis and neuroregeneration are insufficient for brain repair and brain function restoration. Understanding the mechanisms of endogenous brain repair, as well as their roles in reducing and alleviating secondary brain injury could lead to novel therapeutical approaches for promoting brain repair and improving brain function. Over the past decades, many molecular and cellular mechanisms of endogenous brain repair`, such as anti-inflammation, anti-oxidation, and anti-apoptosis, have been extensively studied. However, other mechanisms, such as waste clearance, still need to be further investigated.
This Research Topic aims to gain a better understanding of the mechanisms of endogenous brain repair after acute or chronic brain injury in cerebrovascular diseases. We hope that this Research Topic will provide new insights into the development of novel therapeutic approaches for treating brain injuries and restoring brain function in a variety of cerebrovascular diseases.
We welcome all Original Research articles and Reviews that focus on, but not limited to, the following topics:
-The mechanisms of endogenous brain repair in cerebrovascular diseases, such as the role of scavenger receptors, glial activation, glymphatic system, phagocytosis, autophagy, and their regulatory pathways in the brain repair processes.
- The common and different mechanism of endogenous brain repair among different cerebrovascular diseases, including stroke (acute ischemic or hemorrhagic accident), chronic cerebrovascular diseases (cerebral small vessel diseases, amyloid angiopathy, central nervous system vasculitis, leucoaraiosis).
- The translational research for treating brain injury in cerebrovascular diseases, such as identify novel therapeutical targets that could directly stimulate endogenous neurogenesis and neuroregeneration for brain repair.
- The endogenous repair mechanisms for treating cognitive impairments in cerebrovascular diseases.