Research Topic

The role of choroid plexus in brain disorders

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The choroid plexus epithelium has functions as a barrier at the interface between the blood and cerebrospinal fluid (CSF) highly differentiated. The choroid plexus is located within cerebral ventricles and form the barrier called Blood-CDF-barrier (BCSFB). Choroid plexus formed by a tight epithelial cell ...

The choroid plexus epithelium has functions as a barrier at the interface between the blood and cerebrospinal fluid (CSF) highly differentiated. The choroid plexus is located within cerebral ventricles and form the barrier called Blood-CDF-barrier (BCSFB). Choroid plexus formed by a tight epithelial cell monolayer around a core of capillaries and connective tissue. The epithelial layer is continuous with the layer of ependymal cells that line the ventricles, but unlike the ependyma, choroid plexus have tight junctions between the cells on the side facing the ventricle, known as the apical surface. Ependymal cells covering the choroid plexus, as other secretory epithelia have a polarized distribution of specific transporters.
In the recent years, much attention has been directed to the roles of the choroid plexus in the central nervous system under both normal and pathological conditions. It is well known that the choroid plexus produces and secretes many biologically active neurotrophic factors into the CSF, being responsible for at least two-thirds of the CSF that travels between the spinal cord and brain, providing nutrients and removing waste. This specialized ventricular structure has recently emerged as a key player in a variety of processes that monitor and maintain the biochemical and cellular homeostasis of the brain. In neurodegenerative disease, neurological disease and in acute brain injury there is local up/down-regulation of trophic factors, peptides, hormones, etc. close to the site of the lesion. Also, the choroid plexus progressively fails in its function with age, and in recent year researchers have reason to believe that this failure contributes to conditions such as Alzheimer’s disease, Multiple Sclerosis, Parkinson’s disease and ischemia. In fact, there is recent evidence suggests that the choroid plexus senses inflammation in the periphery, and transmits signals about this to the brain via the CSF. The choroid plexus is equipped to do this, since it is an active site of protein synthesis, and possesses various receptors for molecules involved in the inflammatory process.
The current research topics plan a broad scope to understand the role of choroid plexus in different brain diseases and promote communication among researchers in different disciplines to understand how the choroid plexus and brain function synergistically interact to affect neurodegenerative and neurological diseases


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