Cellular stress is a complex physiological event evolved to either promote cell survival or eliminate damaged or unwanted cells. Biochemical responses to stress factors depend on the magnitude of external damage that affects cell homeostasis. These different defense mechanisms, reacting to different levels and types of stress, determine cell survival.
Aberrant cellular stress responses are closely linked to various pathologies in the nervous system. Specifically, a growing body of recent evidence suggests that cellular stress plays a central role in the inflammatory events characterizing different neurodegenerative disorders. Chronic neuroinflammation has been described as a driving force of neurodegenerative processes. As well, in the impaired nervous system, glia and infiltrating peripheral immune cells appear to play a role in immunomodulatory dysfunctions that can alter neuronal transmission, synaptic plasticity and pruning, and lead to cognitive, emotional and motor deficits. Among the different cellular stress responses, chronic stress granules can also play a pivotal role in contributing to the pathogenesis of various neurodegenerative diseases.
A better understanding of these molecular mechanisms underlying stress-related inflammation in neurodegeneration will not only enable a better understanding but also pave the way for the development of molecular targeted treatment approaches. To this effect, research conducted on the molecular mechanism of action of phytochemicals against anti-inflammatory effects may be equally important.
The aim of this Research Topic is to better understand the relationship between the cellular stress response and inflammation in the onset and/or progression of neurodegenerative disorders, and to explore novel actors and new therapeutic strategies for neuroprotection in aging.
We welcome contributions to this Topic that include, but are not limited to:
- The role of the cellular stress response mechanism and inflammation in age-related neurodegenerations
- The evaluation of markers of the cellular stress response and inflammation in patients affected by age-related diseases
- The Design, synthesis and assessment of synthetic or natural molecules targeting inflammation and cellular stress for the treatment of age-related neurodegeneration
- The mechanisms involved in the cellular stress response and inflammation in neurodegenerative and age-related disease, including the role of gut-brain axis and microbiota
- New therapeutic strategies to counteract the adverse effects of cellular stress correlated to neurological alterations, inflammation and aging
- The role of cells of other non-neuronal cells in the brain (immune system and endothelial cells, astrocytes and microglia) and mediators of cell-cell communication
Cellular stress is a complex physiological event evolved to either promote cell survival or eliminate damaged or unwanted cells. Biochemical responses to stress factors depend on the magnitude of external damage that affects cell homeostasis. These different defense mechanisms, reacting to different levels and types of stress, determine cell survival.
Aberrant cellular stress responses are closely linked to various pathologies in the nervous system. Specifically, a growing body of recent evidence suggests that cellular stress plays a central role in the inflammatory events characterizing different neurodegenerative disorders. Chronic neuroinflammation has been described as a driving force of neurodegenerative processes. As well, in the impaired nervous system, glia and infiltrating peripheral immune cells appear to play a role in immunomodulatory dysfunctions that can alter neuronal transmission, synaptic plasticity and pruning, and lead to cognitive, emotional and motor deficits. Among the different cellular stress responses, chronic stress granules can also play a pivotal role in contributing to the pathogenesis of various neurodegenerative diseases.
A better understanding of these molecular mechanisms underlying stress-related inflammation in neurodegeneration will not only enable a better understanding but also pave the way for the development of molecular targeted treatment approaches. To this effect, research conducted on the molecular mechanism of action of phytochemicals against anti-inflammatory effects may be equally important.
The aim of this Research Topic is to better understand the relationship between the cellular stress response and inflammation in the onset and/or progression of neurodegenerative disorders, and to explore novel actors and new therapeutic strategies for neuroprotection in aging.
We welcome contributions to this Topic that include, but are not limited to:
- The role of the cellular stress response mechanism and inflammation in age-related neurodegenerations
- The evaluation of markers of the cellular stress response and inflammation in patients affected by age-related diseases
- The Design, synthesis and assessment of synthetic or natural molecules targeting inflammation and cellular stress for the treatment of age-related neurodegeneration
- The mechanisms involved in the cellular stress response and inflammation in neurodegenerative and age-related disease, including the role of gut-brain axis and microbiota
- New therapeutic strategies to counteract the adverse effects of cellular stress correlated to neurological alterations, inflammation and aging
- The role of cells of other non-neuronal cells in the brain (immune system and endothelial cells, astrocytes and microglia) and mediators of cell-cell communication
