SARS-CoV-2 has caused serious threats to human health worldwide. COVID-19 is multisystem disease that primarily affects pulmonary system and is linked with extrapulmonary conditions such as gastrointestinal, cardiological, and neurological manifestations. It affects central nervous system (CNS) and peripheral nervous system (PNS) to cause neurological symptoms such as dizziness, headache, fatigue, and loss of smell and taste. COVID-19 infection has also been reported to increase the risk of acute cerebrovascular disease and the associated neurological conditions. Although there already have been research reporting the presence of viral RNA in brain, its route of entering CNS has not been confirmed yet. One of the indications that SARS-CoV-2 increases the risk of neurological conditions is cytokine storm or immunological responses. In severe cases, COVID-19 exacerbates inflammatory process by increasing the concentrations of pro-inflammatory cytokines, which in turn can cause cerebrovascular diseases. Besides the need of understanding the mechanisms associated with infectiousness, effective therapeutic options are also required to treat the infection as well as to mitigate the risk of neurological conditions.
COVID-19 has been widely studied in the aspects of clinical indications, infectiousness, transmission, and immunological responses; it has also been found to be associated with non-respiratory health problems such as neurological conditions. It is yet to investigate that how SARS-CoV-2 infection increases the risk of neurological diseases/disorders. Moreover, effective therapeutic options to treat COVID-19 diseases, and strategies to manage long term impacts of neurological conditions or reduce the risk of neurological conditions are yet to develop. Considering the importance of brain’s health, this research topic focuses on understanding the connections between SARS-CoV-2/COVID-19 and neurological conditions, and the development of effective treatment strategies to target virus and improve brain’s health.
This Research Topic aims to discover the infectiousness of COVID-19, the associated neurological consequences, and therapeutic/preventive options. Authors are welcomed to contribute Research Articles, Mini Reviews and Reviews, and Communications on the related topics. Topics to be covered in the Research Topic may include, but not limited to:
• Epidemiological and clinical inter-connections of COVID-19 and pre-existing or COVID-19 mediated neurological conditions (mechanisms of transmission, infectiousness, and consequences)
• Cytokines storm and immunological responses associated with neurological manifestations of COVID-19
• Risk of cerebrovascular diseases in patients with COVID-19 infection
• Underlying molecular mechanisms of COVID-19 and the neurological manifestations of COVID-19 (such as the unresolved mechanisms of viral entry into the CNS)
• Therapeutic options for COVID-19 and secondary neurological complications of COVID-19
• Development of preventive measures in patients with chronic neurological conditions (such as stroke)
SARS-CoV-2 has caused serious threats to human health worldwide. COVID-19 is multisystem disease that primarily affects pulmonary system and is linked with extrapulmonary conditions such as gastrointestinal, cardiological, and neurological manifestations. It affects central nervous system (CNS) and peripheral nervous system (PNS) to cause neurological symptoms such as dizziness, headache, fatigue, and loss of smell and taste. COVID-19 infection has also been reported to increase the risk of acute cerebrovascular disease and the associated neurological conditions. Although there already have been research reporting the presence of viral RNA in brain, its route of entering CNS has not been confirmed yet. One of the indications that SARS-CoV-2 increases the risk of neurological conditions is cytokine storm or immunological responses. In severe cases, COVID-19 exacerbates inflammatory process by increasing the concentrations of pro-inflammatory cytokines, which in turn can cause cerebrovascular diseases. Besides the need of understanding the mechanisms associated with infectiousness, effective therapeutic options are also required to treat the infection as well as to mitigate the risk of neurological conditions.
COVID-19 has been widely studied in the aspects of clinical indications, infectiousness, transmission, and immunological responses; it has also been found to be associated with non-respiratory health problems such as neurological conditions. It is yet to investigate that how SARS-CoV-2 infection increases the risk of neurological diseases/disorders. Moreover, effective therapeutic options to treat COVID-19 diseases, and strategies to manage long term impacts of neurological conditions or reduce the risk of neurological conditions are yet to develop. Considering the importance of brain’s health, this research topic focuses on understanding the connections between SARS-CoV-2/COVID-19 and neurological conditions, and the development of effective treatment strategies to target virus and improve brain’s health.
This Research Topic aims to discover the infectiousness of COVID-19, the associated neurological consequences, and therapeutic/preventive options. Authors are welcomed to contribute Research Articles, Mini Reviews and Reviews, and Communications on the related topics. Topics to be covered in the Research Topic may include, but not limited to:
• Epidemiological and clinical inter-connections of COVID-19 and pre-existing or COVID-19 mediated neurological conditions (mechanisms of transmission, infectiousness, and consequences)
• Cytokines storm and immunological responses associated with neurological manifestations of COVID-19
• Risk of cerebrovascular diseases in patients with COVID-19 infection
• Underlying molecular mechanisms of COVID-19 and the neurological manifestations of COVID-19 (such as the unresolved mechanisms of viral entry into the CNS)
• Therapeutic options for COVID-19 and secondary neurological complications of COVID-19
• Development of preventive measures in patients with chronic neurological conditions (such as stroke)
