T cell is an essential component of the adaptive immune response in infection. Controlling the metabolic processes within T cells provides a critical way of immune regulation that is interlinked with nutrient sensing and the continued balancing of stimulatory and inhibitory signals. T-cell responses to infection control is a concerto, mingling phenotypic and functional adaptations, ensuring adequate nutrient uptake and utilization. T cell exhaustion responding to persistent infections often exhibits a dysregulated metabolic profile, driven by a combination of chronic antigenic stimulation and signals from the local microenvironment. Understanding the alterations in these metabolic processes provides an important basis for disease risk assessment or immunotherapeutic strategies to treat persistent infections.
The goal of this Research Topic is to provide a forum to advance research on exploring metabolic mechanisms of T cell immunity to fight infections. Furthermore, we discuss the potential approaches and applications in which T cells might be manipulated by the reprogramming of metabolic pathways for therapeutic purposes. Developing immunometabolic checkpoints as biomarkers for diagnosis or patient monitoring in complicate infectious diseases (eg. sepsis) is also our topic goal.
We welcome the submissions of Original Research and Review on the sub-topics below:
1) Immune metabolic mechanisms of T cell response to infections
2) The impact of the systemic metabolic and/or microbiome alterations on immune cell function during infection
3) Developing metabolic checkpoints in T cells as biomarkers for diagnosis or immune monitoring in infectious diseases
4) Combination therapy studies–e.g. traditional treatment plus targeting T cell metabolism
5) Translational research in immunometabolism of infection
T cell is an essential component of the adaptive immune response in infection. Controlling the metabolic processes within T cells provides a critical way of immune regulation that is interlinked with nutrient sensing and the continued balancing of stimulatory and inhibitory signals. T-cell responses to infection control is a concerto, mingling phenotypic and functional adaptations, ensuring adequate nutrient uptake and utilization. T cell exhaustion responding to persistent infections often exhibits a dysregulated metabolic profile, driven by a combination of chronic antigenic stimulation and signals from the local microenvironment. Understanding the alterations in these metabolic processes provides an important basis for disease risk assessment or immunotherapeutic strategies to treat persistent infections.
The goal of this Research Topic is to provide a forum to advance research on exploring metabolic mechanisms of T cell immunity to fight infections. Furthermore, we discuss the potential approaches and applications in which T cells might be manipulated by the reprogramming of metabolic pathways for therapeutic purposes. Developing immunometabolic checkpoints as biomarkers for diagnosis or patient monitoring in complicate infectious diseases (eg. sepsis) is also our topic goal.
We welcome the submissions of Original Research and Review on the sub-topics below:
1) Immune metabolic mechanisms of T cell response to infections
2) The impact of the systemic metabolic and/or microbiome alterations on immune cell function during infection
3) Developing metabolic checkpoints in T cells as biomarkers for diagnosis or immune monitoring in infectious diseases
4) Combination therapy studies–e.g. traditional treatment plus targeting T cell metabolism
5) Translational research in immunometabolism of infection
