Research Topic

Neurovascular Dysfunction After Stroke

About this Research Topic

The pathophysiology of stroke is complex and is not limited to neuronal damage only. Neurovascular dysfunction, as a consequence of the impaired crosstalk between neurons, glia, and vascular compartments, is an early event following stroke. Neurovascular dysfunction is critically involved in the development of hemorrhagic transformation, brain edema, neuroinflammation and cell death after stroke. A better understanding of the molecular mechanisms underlying neurovascular dysfunction following stroke may have important implications for the treatment of brain injury after stroke.

The goal of this special issue is to highlight recent advances in the pathophysiology, diagnosis, and potential therapeutic targets of neurovascular injury that occurs following stroke. Original research articles and review that contribute to the translation of laboratory studies into a clinical setting and clinical observation are welcome. Areas of interest include, but are not limited to the following:

• The signaling pathways underlying neurovascular dysfunction after stroke.
• Novel diagnostic markers and therapeutic targets for post-stroke hemorrhagic transformation and brain edema.
• The interplay between neuroinflammation and neurovascular injuries.
• Impaired cerebral autoregulation and neurovascular coupling.
• Remodeling and recovery of neurovascular unit after stroke.


Keywords: Neurovascular dysfunction, stroke, hemorrhagic transformation, brain edema


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The pathophysiology of stroke is complex and is not limited to neuronal damage only. Neurovascular dysfunction, as a consequence of the impaired crosstalk between neurons, glia, and vascular compartments, is an early event following stroke. Neurovascular dysfunction is critically involved in the development of hemorrhagic transformation, brain edema, neuroinflammation and cell death after stroke. A better understanding of the molecular mechanisms underlying neurovascular dysfunction following stroke may have important implications for the treatment of brain injury after stroke.

The goal of this special issue is to highlight recent advances in the pathophysiology, diagnosis, and potential therapeutic targets of neurovascular injury that occurs following stroke. Original research articles and review that contribute to the translation of laboratory studies into a clinical setting and clinical observation are welcome. Areas of interest include, but are not limited to the following:

• The signaling pathways underlying neurovascular dysfunction after stroke.
• Novel diagnostic markers and therapeutic targets for post-stroke hemorrhagic transformation and brain edema.
• The interplay between neuroinflammation and neurovascular injuries.
• Impaired cerebral autoregulation and neurovascular coupling.
• Remodeling and recovery of neurovascular unit after stroke.


Keywords: Neurovascular dysfunction, stroke, hemorrhagic transformation, brain edema


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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