About this Research Topic
The pathophysiology of stroke is complex and is not limited to neuronal damage only. Neurovascular dysfunction, as a consequence of the impaired crosstalk between neurons, glia, and vascular compartments, is an early event following stroke. Neurovascular dysfunction is critically involved in the development of hemorrhagic transformation, brain edema, neuroinflammation and cell death after stroke. A better understanding of the molecular mechanisms underlying neurovascular dysfunction following stroke may have important implications for the treatment of brain injury after stroke.
The goal of this special issue is to highlight recent advances in the pathophysiology, diagnosis, and potential therapeutic targets of neurovascular injury that occurs following stroke. Original research articles and review that contribute to the translation of laboratory studies into a clinical setting and clinical observation are welcome. Areas of interest include, but are not limited to the following:
• The signaling pathways underlying neurovascular dysfunction after stroke.
• Novel diagnostic markers and therapeutic targets for post-stroke hemorrhagic transformation and brain edema.
• The interplay between neuroinflammation and neurovascular injuries.
• Impaired cerebral autoregulation and neurovascular coupling.
• Remodeling and recovery of neurovascular unit after stroke.
Keywords: Neurovascular dysfunction, stroke, hemorrhagic transformation, brain edema
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