The relationship between systemic inflammation and cancer development and progression is a massively complex topic of medicine and surgery in general. Over the last decades, many studies have focused on the prognostic relevance of preoperative inflammatory status in diverse oncology settings, including lung cancer. As far as postoperative inflammatory response is concerned, there are suggestions that it may result in a transient yet remarkable inhibition of anticancer defense mechanisms. The degree of perioperative inflammation would therefore affect long term outcomes, by promoting early tumor spread. However, the amount of research dealing with this specific aspect is scant.
This Research Topic has a twofold goal. The first one, is to elaborate whether an excess systemic inflammation is associated with long term outcomes in patients who receive curative-intent surgery for lung cancer. The second goal is to investigate whether different strategies (including surgical approach, anesthesia techniques and perioperative medications) might help modulate the degree of perioperative inflammation, with a view to possible beneficial effects in practical terms.
We would welcome clinical studies, animal studies or basic science investigations addressing specifically the questions and goals described above. While being this Research Topic focused on surgical management of lung cancer, valuable contributions from other surgical and medical specialties - the results of which may open new horizons to thoracic practice - will be given the highest consideration.
The relationship between systemic inflammation and cancer development and progression is a massively complex topic of medicine and surgery in general. Over the last decades, many studies have focused on the prognostic relevance of preoperative inflammatory status in diverse oncology settings, including lung cancer. As far as postoperative inflammatory response is concerned, there are suggestions that it may result in a transient yet remarkable inhibition of anticancer defense mechanisms. The degree of perioperative inflammation would therefore affect long term outcomes, by promoting early tumor spread. However, the amount of research dealing with this specific aspect is scant.
This Research Topic has a twofold goal. The first one, is to elaborate whether an excess systemic inflammation is associated with long term outcomes in patients who receive curative-intent surgery for lung cancer. The second goal is to investigate whether different strategies (including surgical approach, anesthesia techniques and perioperative medications) might help modulate the degree of perioperative inflammation, with a view to possible beneficial effects in practical terms.
We would welcome clinical studies, animal studies or basic science investigations addressing specifically the questions and goals described above. While being this Research Topic focused on surgical management of lung cancer, valuable contributions from other surgical and medical specialties - the results of which may open new horizons to thoracic practice - will be given the highest consideration.