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Calcium channel blockers (CCBs) are the oldest drugs to manage pulmonary hypertension. Until now, CCBs are still the first choice of a certain kind of pulmonary arterial hypertension. And more researches have shown that calcium can influence pulmonary endothelial cells and smooth muscle cells through ...

Calcium channel blockers (CCBs) are the oldest drugs to manage pulmonary hypertension. Until now, CCBs are still the first choice of a certain kind of pulmonary arterial hypertension. And more researches have shown that calcium can influence pulmonary endothelial cells and smooth muscle cells through different kinds of calcium channels and pathways. And more researches have shown that calcium is involved in different types of pulmonary hypertension, including idiopathic pulmonary arterial hypertension, hypoxic pulmonary hypertension and chronic thromboembolic pulmonary hypertension.

This Research Topic aims to collect data on the relationship and mechanism of calcium and pulmonary hypertension and find new promising drugs for pulmonary hypertension. We welcome the submission of Reviews and Original Research articles.

Areas to be covered in this Research Topic may include, but are not limited to:

• Role of CaSR and its mechanism in pulmonary hypertension
• Calcium channel and its molecular proteins such as TRP family and corresponding signalling pathways
• Role and mechanism of halofuginone and other extractions of herbaceous medicine in pulmonary hypertension
• New insight in the treatment of pulmonary hypertension
• Acute vasodilator testing and pulmonary hypertension

Keywords: calcium channel blockers, calcium, calcium channel, pulmonary hypertension, acute vasodilator testing, calcium-sensing receptor, halofuginone


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