About this Research Topic
However, a combination of recent technological advances and an increasingly prominent role of cellular immunity in important biomedical applications, including cancer immunotherapy and the response to the COVID-19 pandemic, has promoted a renewed interest in T-cell cross-reactivity quantification and prediction. In this context, the goal of this Research Topic is to serve as a focal point for ongoing research on T-cell cross-reactivity, providing an updated and integrated overview of both experimental and computational efforts that are being pursued across different fields of immunology, virology, oncology and biotechnology. By focusing on new methods for quantification and prediction of T-cell cross-reactivity, in addition to research findings associated with these methods, we aim to further accelerate progress towards a deeper and broader understanding of this phenomenon, therefore paving the way for meaningful biomedical applications.
In this collection, we welcome the submission of Original Research, Review/Mini-review, Case Report, Hypothesis and Theory, Perspective and Opinion articles on topics related to T-cell specificity and cross-reactivity, including, but not limited to, the following themes:
• High-throughput experimental methods for the determination of T-cell specificity
• Experimental methods for quantifying T-cell cross-reactivity in immunotherapy
• Identification of pathogen-specific T-cells in tumor infiltrates
• The role of T-cell cross-reactivity in autoimmunity and tolerance
• The role of T-cell cross-reactivity in the interaction with the microbiome
• The impact of T-cell cross-reactivity in transplant rejection and graft versus host disease
• Quantification of heterologous immunity in cellular response to vaccination
• Assessment of non-reciprocal responses in T-cell cross-reactivity (i.e., directionality)
• Specificity and cross-reactivity of gamma-delta T-Cells
• Phenotypic characterization of cross-reactive memory T-cells
• Analysis of public and private cross-reactive T-cell repertoires in immunotherapy
• Computational prediction of T-cell specificity from TCR sequences or structures
• Computational prediction of the risk for off-target toxicity in immunotherapy applications
• Virtual screening of potential cross-reactive targets
• Tools and databases on TCRs and/or peptide-MHC targets
• Structural modeling and analysis of TCR-peptide-MHC interactions
• Computer-aided design of safer TCR-based therapeutics
• Theoretical considerations of T-cell and TCR cross-reactivity
Keywords: T-cell cross-reactivity, heterologous immunity, T-cell specificity, polyspecificity, T-cell repertoire, peptide-MHC hotspots, TCR, CDR.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.