Cells perform long-range intercellular transfer to maintain cellular homeostasis in normal physiology and in various pathological conditions. In the last two decades, several studies have implicated exosomes and tunneling nanotubes (TNTs), as long-range intercellular transfer modes in neurological diseases. Exosomes, the smallest extracellular nano-vesicles, transfer between physically disconnected cells, whereas TNTs make direct bridges through open-ended actin membrane nanotubes to propagate transfer between two distal cells. Recent studies have shown that the biogenesis pathways of exosomes and TNTs interface with several common molecular events and are involved together in various pathological processes. Pathogenesis related to lysosomal toxicity, oxidative stress, and intracellular trafficking may have links to the formation of both exosomes and TNTs, which have been implicated in various neurological disorders, including neuroendocrine tumors, brain tumors, such as glioblastoma, medulloblastoma, and neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, tauopathies, Amyotrophic lateral sclerosis and Prion disease.
The goal of this Research Topic is to update the current status and highlight new hypotheses related to molecular signaling and biogenesis of long-range intercellular transfer modes and their implications in neurological diseases. Exosomes and TNTs are important areas of focus, and several research articles implicate the emerging role of these transfer processes. In addition, exosomes and TNTs derived from mesenchymal stem cells have therapeutic potential.
The Research Topic will include original research and reviews on potential molecular pathogenesis in neurological diseases that could trigger long-range intercellular communications in pathology progression and therapy, for example:
- Molecular signaling pathways in pathology progression of neurological diseases
- Neurodegenerative proteins in exosomes and/or TNTs
- Exosomes and/or TNTs in pathology propagation in neurodegenerative diseases
- Exosomes and/or TNTs in neuroendocrine tumors
- Molecular signaling pathways in the biogenesis of exosomes and/or TNTs
- Endo-lysosomal toxicities in the biogenesis of exosomes and/or TNTs
- Oxidative stress in the biogenesis of exosomes and/or TNTs
- Therapeutic potentials of exosomes and TNTs in neurological diseases
Cells perform long-range intercellular transfer to maintain cellular homeostasis in normal physiology and in various pathological conditions. In the last two decades, several studies have implicated exosomes and tunneling nanotubes (TNTs), as long-range intercellular transfer modes in neurological diseases. Exosomes, the smallest extracellular nano-vesicles, transfer between physically disconnected cells, whereas TNTs make direct bridges through open-ended actin membrane nanotubes to propagate transfer between two distal cells. Recent studies have shown that the biogenesis pathways of exosomes and TNTs interface with several common molecular events and are involved together in various pathological processes. Pathogenesis related to lysosomal toxicity, oxidative stress, and intracellular trafficking may have links to the formation of both exosomes and TNTs, which have been implicated in various neurological disorders, including neuroendocrine tumors, brain tumors, such as glioblastoma, medulloblastoma, and neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, tauopathies, Amyotrophic lateral sclerosis and Prion disease.
The goal of this Research Topic is to update the current status and highlight new hypotheses related to molecular signaling and biogenesis of long-range intercellular transfer modes and their implications in neurological diseases. Exosomes and TNTs are important areas of focus, and several research articles implicate the emerging role of these transfer processes. In addition, exosomes and TNTs derived from mesenchymal stem cells have therapeutic potential.
The Research Topic will include original research and reviews on potential molecular pathogenesis in neurological diseases that could trigger long-range intercellular communications in pathology progression and therapy, for example:
- Molecular signaling pathways in pathology progression of neurological diseases
- Neurodegenerative proteins in exosomes and/or TNTs
- Exosomes and/or TNTs in pathology propagation in neurodegenerative diseases
- Exosomes and/or TNTs in neuroendocrine tumors
- Molecular signaling pathways in the biogenesis of exosomes and/or TNTs
- Endo-lysosomal toxicities in the biogenesis of exosomes and/or TNTs
- Oxidative stress in the biogenesis of exosomes and/or TNTs
- Therapeutic potentials of exosomes and TNTs in neurological diseases
