For more than 20 years, the disciplines of metabolomics and assisted reproduction have intersected. Metabolomic approaches have assisted in clarifying the cellular and molecular mechanisms involved in oocyte and spermatozoa fertilization competency, embryo development and endometrial receptivity. Moreover, there remains hope that metabolomic methodologies will identify biomarkers of a range of infertility pathophysiologies that may not be diagnosed during routine infertility investigation. Novel methods of evaluating metabolic profiles, generated via metabolomic methods may ultimately lead to enhancement of assisted reproduction cycle success rates by providing unbiased indicators of ovarian reserve and function, gamete fertilization potential, embryo viability and receptivity of the endometrium.
The goal of this research topic is to reflect on the impact of metabolomics in assisted reproduction, and contribute in reaching a consensus regarding current state of the art. This research topic aims to present novel studies on the application of metabolomics in ART, serving as a reference point for the current state of the art as well as highlighting future priority areas for research.
Different types of articles are eligible including original articles, systematic reviews and meta-analysis, critical reviews as well as proof-of-concept studies.
Topics of interest include, but are not limited to:
• Metabolomic biomarkers for assessing male infertility
• Metabolomic evaluation of oocyte competence
• The role of metabolomics for assessing embryo viability and successful IVF cycle outcome
• Metabolomic biomarkers for female infertility pathophysiologies
For more than 20 years, the disciplines of metabolomics and assisted reproduction have intersected. Metabolomic approaches have assisted in clarifying the cellular and molecular mechanisms involved in oocyte and spermatozoa fertilization competency, embryo development and endometrial receptivity. Moreover, there remains hope that metabolomic methodologies will identify biomarkers of a range of infertility pathophysiologies that may not be diagnosed during routine infertility investigation. Novel methods of evaluating metabolic profiles, generated via metabolomic methods may ultimately lead to enhancement of assisted reproduction cycle success rates by providing unbiased indicators of ovarian reserve and function, gamete fertilization potential, embryo viability and receptivity of the endometrium.
The goal of this research topic is to reflect on the impact of metabolomics in assisted reproduction, and contribute in reaching a consensus regarding current state of the art. This research topic aims to present novel studies on the application of metabolomics in ART, serving as a reference point for the current state of the art as well as highlighting future priority areas for research.
Different types of articles are eligible including original articles, systematic reviews and meta-analysis, critical reviews as well as proof-of-concept studies.
Topics of interest include, but are not limited to:
• Metabolomic biomarkers for assessing male infertility
• Metabolomic evaluation of oocyte competence
• The role of metabolomics for assessing embryo viability and successful IVF cycle outcome
• Metabolomic biomarkers for female infertility pathophysiologies
