About this Research Topic
Outer retinal degenerative diseases are at present one of the leading causes of irreversible blindness in the world. These diseases have in common their onset with photoreceptor loss, although their pathophysiological mechanisms may vary according to the disease, and that they inevitably lead to blindness. Understanding the events involved in retinal remodeling will allow scientists to find windows of opportunity to develop vision-rescuing therapies for retinal degenerative diseases that currently lack effective treatment, as is the case for AMD and RP.
Original research papers, literature reviews, and mini-reviews covering any aspect of retinal remodeling, from its early stages to secondary inner retinal neurodegeneration, or its potential therapies, are welcome for this Research Topic.
Keywords: Photoreceptor degeneration, Inherited retinal degeneration, Induced retinal degeneration, Microglia, Macroglia, Glial seal, Apoptosis, Photoreceptor neuroprotection, Cell transplantation, Retinal prostheses, Gene therapy, Exosomes, Retinal implants, Optogenetics, Organoids, Retinal ganglion cells
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