Hepatic ischemia-reperfusion (I/R) injury is a common physiological phenomenon in trauma, liver transplantation, resection, and hemorrhagic shock. The hepatic I/R injury contributes to an increased rate of acute liver failure, graft rejection, and chronic hepatic dysfunction. The mechanisms underlying the development of hepatic I/R are complex and diverse, involving endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) production, mitochondrial dysfunction, inflammation, Ca2+ overload, autophagy, apoptosis, and necroptosis. However, currently, there are no clinically approved drugs available to treat severe liver ischemia-reperfusion injury.
The roles of the liver nonparenchymal cells, especially immune cells, such as Kupffer cells, neutrophils, and regulatory T cells, in the pathogenesis of hepatic I/R are still unclear. Furthermore, the functional roles of the hepatic stellate cells and sinusoidal endothelial cells are still not well understood in hepatic I/R. I/R-induced liver injury activates or recruits many different immune cells from the blood, bone marrow, and other immune organs and tissues. However, the differential roles of local and circulatory immune cells in hepatic I/R-triggered liver inflammation remain elusive.
This Research Topic aims to collect manuscripts focusing on the contribution of immune cells to the pathogenesis and development of hepatic ischemia-reperfusion. We also welcome submissions focusing on related immune cell regulatory mechanisms in the management of ischemia-reperfusion injury. We welcome the submission of manuscripts investigating the distinct roles of local immune cells and circulatory immune cells in liver ischemia-reperfusion injury. We welcome submissions covering, but not limited to, the following sub-topics:
1) Mechanisms of Kupffer cells, neutrophils, and regulatory T cells in hepatic ischemia-reperfusion
2) The differential roles of Kupffer cells and bone marrow-derived macrophages during hepatic ischemia-reperfusion
3) The functional roles of immune cells and their related mechanisms in different stages of hepatic ischemia-reperfusion
4) The cross-talk between immune cells and hepatocytes in hepatic ischemia-reperfusion
5) The functional roles of Hepatic Stellate Cells and their related mechanisms in different stages of hepatic ischemia-reperfusion
6) The roles of liver sinusoidal endothelial cells in different stages of hepatic ischemia-reperfusion
Hepatic ischemia-reperfusion (I/R) injury is a common physiological phenomenon in trauma, liver transplantation, resection, and hemorrhagic shock. The hepatic I/R injury contributes to an increased rate of acute liver failure, graft rejection, and chronic hepatic dysfunction. The mechanisms underlying the development of hepatic I/R are complex and diverse, involving endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) production, mitochondrial dysfunction, inflammation, Ca2+ overload, autophagy, apoptosis, and necroptosis. However, currently, there are no clinically approved drugs available to treat severe liver ischemia-reperfusion injury.
The roles of the liver nonparenchymal cells, especially immune cells, such as Kupffer cells, neutrophils, and regulatory T cells, in the pathogenesis of hepatic I/R are still unclear. Furthermore, the functional roles of the hepatic stellate cells and sinusoidal endothelial cells are still not well understood in hepatic I/R. I/R-induced liver injury activates or recruits many different immune cells from the blood, bone marrow, and other immune organs and tissues. However, the differential roles of local and circulatory immune cells in hepatic I/R-triggered liver inflammation remain elusive.
This Research Topic aims to collect manuscripts focusing on the contribution of immune cells to the pathogenesis and development of hepatic ischemia-reperfusion. We also welcome submissions focusing on related immune cell regulatory mechanisms in the management of ischemia-reperfusion injury. We welcome the submission of manuscripts investigating the distinct roles of local immune cells and circulatory immune cells in liver ischemia-reperfusion injury. We welcome submissions covering, but not limited to, the following sub-topics:
1) Mechanisms of Kupffer cells, neutrophils, and regulatory T cells in hepatic ischemia-reperfusion
2) The differential roles of Kupffer cells and bone marrow-derived macrophages during hepatic ischemia-reperfusion
3) The functional roles of immune cells and their related mechanisms in different stages of hepatic ischemia-reperfusion
4) The cross-talk between immune cells and hepatocytes in hepatic ischemia-reperfusion
5) The functional roles of Hepatic Stellate Cells and their related mechanisms in different stages of hepatic ischemia-reperfusion
6) The roles of liver sinusoidal endothelial cells in different stages of hepatic ischemia-reperfusion