The prevalence of hyperuricemia and gout has been continuously increasing over the past several decades. Hyperuricemia is a risk factor for gout, but it is well known that it is associated with metabolic syndrome and cardiovascular risk. Gout is also associated with increased cardiovascular risk, and treatment of gout may affect cardiovascular risk. Although it is not clear how hyperuricemia and gout are related to metabolic syndrome and cardiovascular disease, insulin resistance, endothelial dysfunction, oxidative stress, and endoplasmic reticulum stress were suggested as possible mechanisms. Now, Gout is not only an inflammatory disease of the joints, but also a metabolic disease.
This Research Topic aims to elucidate the mechanism by which hyperuricemia and gout act as metabolic risk factors, and to explore the effects of gout itself and its treatment on metabolic syndrome and cardiovascular disease.
We encourage the submission of basic, translational, and clinical researches on the association of hyperuricemia, gout with metabolic syndrome or cardiovascular disease. Here, we welcome original research, reviews, opinion pieces, and clinical trials focusing on the following sample topics:
• Epidemiologic studies focusing on association between gout, hyperuricemia and metabolic disease or cardiovascular risk
• Basic, translational researches on the mechanism by which uric acid acts as metabolic risk factors
• Researches on effect of gout diagnosis or treatment on metabolic disease and cardiovascular disease
The prevalence of hyperuricemia and gout has been continuously increasing over the past several decades. Hyperuricemia is a risk factor for gout, but it is well known that it is associated with metabolic syndrome and cardiovascular risk. Gout is also associated with increased cardiovascular risk, and treatment of gout may affect cardiovascular risk. Although it is not clear how hyperuricemia and gout are related to metabolic syndrome and cardiovascular disease, insulin resistance, endothelial dysfunction, oxidative stress, and endoplasmic reticulum stress were suggested as possible mechanisms. Now, Gout is not only an inflammatory disease of the joints, but also a metabolic disease.
This Research Topic aims to elucidate the mechanism by which hyperuricemia and gout act as metabolic risk factors, and to explore the effects of gout itself and its treatment on metabolic syndrome and cardiovascular disease.
We encourage the submission of basic, translational, and clinical researches on the association of hyperuricemia, gout with metabolic syndrome or cardiovascular disease. Here, we welcome original research, reviews, opinion pieces, and clinical trials focusing on the following sample topics:
• Epidemiologic studies focusing on association between gout, hyperuricemia and metabolic disease or cardiovascular risk
• Basic, translational researches on the mechanism by which uric acid acts as metabolic risk factors
• Researches on effect of gout diagnosis or treatment on metabolic disease and cardiovascular disease
