About this Research Topic
We wish to explore several key and interrelated questions:
1) What are the cellular and system level changes that are induced by psychedelics,
2) What is the altered state of consciousness that arises with psychedelics,
3) How central is the ASC to the therapeutic effects of psychedelics, and
4) What benefits, if any, can be derived from non-ASC psychedelic administration, via either microdosing or the use of non-psychoactive analogues?
We are interested in both clinical and pre-clinical (animal) data that would illuminate any of these questions. We seek papers that will address mechanisms of action of psychedelic agents. We are interested in both acute and lasting cellular and network descriptions of neural changes produced by psychedelic agents, as well as perceptual and behavioral changes which accompany dosing with psychedelic agents. We are particularly interested in the tryptaminergic agents (e.g. LSD, psilocybin/psilocin, dimethyltryptamine, and related analogs) and phenethylamines (e.g. MDMA). We are open also to papers on other putative hallucinogens like dissociative and hypnotic drugs in cases where there appears to be therapeutic potential that is associated with an ASC.
We will seek a variety of paper types, including Original Research, Hypothesis and Theory, and Conceptual Analysis, as well as Systematic Reviews and Mini Reviews (see https://www.frontiersin.org/journals/neuroscience#article-types for descriptions of the article types).
Matthew McMurray has received a research grant from PsyBio Therapeutics, Inc. and is a member of the scientific advisory board for PsyBio Therapeutics, Inc.
Keywords: Psychedelics, altered state of consciousness, clinical, preclinical, mechanism of action, cellular, systems
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.