Exercise and physical activity are well-established maneuvers for the prevention of various metabolic diseases including type 2 diabetes. Whole-body energy homeostasis is improved by both acute and chronic exercise in healthy subjects and patients with type 2 diabetes and exercise-induced adaptations in skeletal muscle are likely important for this improvement. In the past couple of decades, the molecular mechanisms responsible for improving whole-body and skeletal muscle energy metabolism in response to exercise have partly been revealed, however, much has still to be uncovered and investigated for potential health beneficial effects.
The whole-body and skeletal muscle metabolic adaptations, such as improved insulin sensitivity and oxidative capacity, are partly explained by transcriptional and post-translational modifications following each individual bout of exercise. However, these revealed mechanisms still do not explain the full adaptive metabolic phenotype that is induced by exercise. This is likely explained by limitations in study designs that focus on one or few specific molecular pathways but do not consider interactions between a vast amount of exercise-induced regulatory proteins. In addition, molecules other than proteins (e.g. lipids and metabolites) are also involved in mediating effects of exercise that highlights the complexity of illuminating exercise-adaptive responses. In recent years, omics analysis technologies have been growing and has resulted in the identification of new regulatory signaling networks and previously unknown regulatory molecules. This has created the basis for numerous new hypothesis and ideas on how exercise may promote whole-body and skeletal muscle energy metabolism.
The scope of this Research Topic is to provide new insight in to the regulation of exercise-induced adaptations in skeletal muscle that contribute to the full effect of exercise in the regulation of whole-body and skeletal muscle energy metabolism. In light of this, we would like to receive original research and reviews exploring the research topic by the use of loss-of-function and/or gain-of-function animal models as well as exercise studies of man. In addition, we also welcome research suggesting novel regulatory mechanisms by unique physiological approaches.
Exercise and physical activity are well-established maneuvers for the prevention of various metabolic diseases including type 2 diabetes. Whole-body energy homeostasis is improved by both acute and chronic exercise in healthy subjects and patients with type 2 diabetes and exercise-induced adaptations in skeletal muscle are likely important for this improvement. In the past couple of decades, the molecular mechanisms responsible for improving whole-body and skeletal muscle energy metabolism in response to exercise have partly been revealed, however, much has still to be uncovered and investigated for potential health beneficial effects.
The whole-body and skeletal muscle metabolic adaptations, such as improved insulin sensitivity and oxidative capacity, are partly explained by transcriptional and post-translational modifications following each individual bout of exercise. However, these revealed mechanisms still do not explain the full adaptive metabolic phenotype that is induced by exercise. This is likely explained by limitations in study designs that focus on one or few specific molecular pathways but do not consider interactions between a vast amount of exercise-induced regulatory proteins. In addition, molecules other than proteins (e.g. lipids and metabolites) are also involved in mediating effects of exercise that highlights the complexity of illuminating exercise-adaptive responses. In recent years, omics analysis technologies have been growing and has resulted in the identification of new regulatory signaling networks and previously unknown regulatory molecules. This has created the basis for numerous new hypothesis and ideas on how exercise may promote whole-body and skeletal muscle energy metabolism.
The scope of this Research Topic is to provide new insight in to the regulation of exercise-induced adaptations in skeletal muscle that contribute to the full effect of exercise in the regulation of whole-body and skeletal muscle energy metabolism. In light of this, we would like to receive original research and reviews exploring the research topic by the use of loss-of-function and/or gain-of-function animal models as well as exercise studies of man. In addition, we also welcome research suggesting novel regulatory mechanisms by unique physiological approaches.
