Exocrine and endocrine pancreases are closely linked anatomically and physiologically. In the past decades, it has been found that both type 1 and type 2 diabetes mellitus are associated with significantly increased risk for pancreatic exocrine insufficiency (PEI), characterized by malabsorption of nutrients and micronutrients, severe gastrointestinal symptoms (including steatorrhea and flatulence), nutritional deficiencies, evident weight loss, and muscle atrophy. Conversely, various exocrine pancreatic diseases, including pancreatitis, trauma, pancreatectomy, and pancreatic neoplasia, can affect the endocrine function of the pancreas and further cause pancreatogenic diabetes, which is also known as type 3c DM (T3cDM). However, the interaction between the endocrine and exocrine pancreas has not been clarified to date. Mechanisms underlying the association between the two remain unclear and need further verification.
This Research Topic aims to provide insight into several facets of the connections between endocrine and exocrine pancreas, and present cutting-edge scientific advances on the potential pathological mechanism of pancreatogenic diabetes in the context of various exocrine pancreatic diseases and related comorbidities, including novel data in relevant animal models and humans.
This Research Topic welcomes:
• Clinical studies on exocrine dysfunction in diabetes mellitus
• Metabolic influences on the exocrine pancreas
• Pathological mechanism of exocrine dysfunction in diabetes mellitus
• Effects of hyperinsulinism on exocrine cells
• Early ultra- and microstructural alterations in the pancreas of diabetes
• Image-based machine learning algorithms for disease characterization
• Clinical studies on various diabetes of the exocrine pancreas (DEP)
• Predict the presence of early-stage pancreatic cancer through the incidence of new-onset diabetes
• Investigate pancreatic and gut hormone responses to mixed meal test
• Identified the potential differential metabolites between T2DM and DEP
• Diagnose and classify diabetes in various diseases of the exocrine pancreas
• Design and perform interventional trials to improve care of patients
• Define the mechanisms of endocrine/exocrine crosstalk
• Profile the phenotype and genotype
• Organoid and pancreas on chip
Exocrine and endocrine pancreases are closely linked anatomically and physiologically. In the past decades, it has been found that both type 1 and type 2 diabetes mellitus are associated with significantly increased risk for pancreatic exocrine insufficiency (PEI), characterized by malabsorption of nutrients and micronutrients, severe gastrointestinal symptoms (including steatorrhea and flatulence), nutritional deficiencies, evident weight loss, and muscle atrophy. Conversely, various exocrine pancreatic diseases, including pancreatitis, trauma, pancreatectomy, and pancreatic neoplasia, can affect the endocrine function of the pancreas and further cause pancreatogenic diabetes, which is also known as type 3c DM (T3cDM). However, the interaction between the endocrine and exocrine pancreas has not been clarified to date. Mechanisms underlying the association between the two remain unclear and need further verification.
This Research Topic aims to provide insight into several facets of the connections between endocrine and exocrine pancreas, and present cutting-edge scientific advances on the potential pathological mechanism of pancreatogenic diabetes in the context of various exocrine pancreatic diseases and related comorbidities, including novel data in relevant animal models and humans.
This Research Topic welcomes:
• Clinical studies on exocrine dysfunction in diabetes mellitus
• Metabolic influences on the exocrine pancreas
• Pathological mechanism of exocrine dysfunction in diabetes mellitus
• Effects of hyperinsulinism on exocrine cells
• Early ultra- and microstructural alterations in the pancreas of diabetes
• Image-based machine learning algorithms for disease characterization
• Clinical studies on various diabetes of the exocrine pancreas (DEP)
• Predict the presence of early-stage pancreatic cancer through the incidence of new-onset diabetes
• Investigate pancreatic and gut hormone responses to mixed meal test
• Identified the potential differential metabolites between T2DM and DEP
• Diagnose and classify diabetes in various diseases of the exocrine pancreas
• Design and perform interventional trials to improve care of patients
• Define the mechanisms of endocrine/exocrine crosstalk
• Profile the phenotype and genotype
• Organoid and pancreas on chip
