Sepsis-associated encephalopathy (SAE) is a key complication of sepsis and is the most frequent type of encephalopathy in the intensive care unit. It affects up to 70% of sepsis patients, and leads to the high mortality and poor long-term outcomes, including cognitive and functional outcomes.
Although several pathogenesis mechanisms have been proposed for SAE, including neurotransmitter dysfunction, inflammatory lesions in the brain, and blood brain barrier dysfunction, the specific causative factors remain unclear and the pathophysiology has not been well-established. In addition, current treatment of SAE is mainly based on the management of sepsis and correction of neurological manifestations, including seizure and delirium. To date, there are few generally accepted suggestions on the treatment of SAE. Increasing knowledge in this field will facilitate the development of targeted interventions.
The focus of this Research Topic is sepsis affecting the central nervous system, especially the brain. We encourage original research articles, case series, clinical research, comprehensive reviews and meta-analysis related to the following themes:
- Basic/experimental research on elucidation of the potential other causative factors or exploring more new other potential mechanisms on SAE, such as: the interaction of systemic inflammation and central nervous inflammation or neurotransmitter or blood brain barrier, and the potential effect of ion channel
- Animal research on exploration of possible pharmacological and non-pharmacological interventions (including stem cells, early exercise as well as acupuncture) for treating SAE
- Basic research on exploration of early pharmacological and non-pharmacological interventions on the mortality and long-term prognosis of SAE
- Clinical research on investigation of pharmacological and non-pharmacological interventions on the mortality and long-term outcome of SAE
- Potential effect of Chinese herbs on SAE
Sepsis-associated encephalopathy (SAE) is a key complication of sepsis and is the most frequent type of encephalopathy in the intensive care unit. It affects up to 70% of sepsis patients, and leads to the high mortality and poor long-term outcomes, including cognitive and functional outcomes.
Although several pathogenesis mechanisms have been proposed for SAE, including neurotransmitter dysfunction, inflammatory lesions in the brain, and blood brain barrier dysfunction, the specific causative factors remain unclear and the pathophysiology has not been well-established. In addition, current treatment of SAE is mainly based on the management of sepsis and correction of neurological manifestations, including seizure and delirium. To date, there are few generally accepted suggestions on the treatment of SAE. Increasing knowledge in this field will facilitate the development of targeted interventions.
The focus of this Research Topic is sepsis affecting the central nervous system, especially the brain. We encourage original research articles, case series, clinical research, comprehensive reviews and meta-analysis related to the following themes:
- Basic/experimental research on elucidation of the potential other causative factors or exploring more new other potential mechanisms on SAE, such as: the interaction of systemic inflammation and central nervous inflammation or neurotransmitter or blood brain barrier, and the potential effect of ion channel
- Animal research on exploration of possible pharmacological and non-pharmacological interventions (including stem cells, early exercise as well as acupuncture) for treating SAE
- Basic research on exploration of early pharmacological and non-pharmacological interventions on the mortality and long-term prognosis of SAE
- Clinical research on investigation of pharmacological and non-pharmacological interventions on the mortality and long-term outcome of SAE
- Potential effect of Chinese herbs on SAE
