Neutrophils have long been recognized as homogeneous cells, but recent evidence has challenged this outdated dogma. High-throughput single-cell methods, including single-cell sequencing and mass spectrometry, have greatly improved our understanding of neutrophil heterogeneity. In tumor microenvironment, both pro-tumoral and anti-tumoral neutrophil subpopulations have been discovered. Although neutrophil subpopulations with distinct immune phenotypes have been reported, a full understanding of neutrophil heterogeneity and the underlying regulatory mechanism remains unclear. In the past decade, metabolic reprogramming of immune cells has attracted much attention. Metabolic reprogramming of neutrophils does not only fulfill the effective energy supply, but also shapes neutrophil immune functions in different pathological conditions. Pro-tumoral and anti-tumoral neutrophil subpopulations are characterized with distinct metabolic status. Investigations into the relationship between neutrophil metabolic heterogeneity and immune phenotypic heterogeneity may favor the understanding of the mechanisms that shape pro-tumoral or anti-tumoral neutrophil subpopulations. Targeting neutrophil metabolic heterogeneity may provide novel therapeutic strategies for tumor immunotherapy.
This Research Topic aims to shed light on investigating neutrophil metabolic heterogeneity in tumor immunotherapy. We welcome contributions in the form of Original Research articles, Reviews and Mini Reviews that cover but are not limited to the following topics related to neutrophil metabolic heterogeneity in cancer.
- Characterization of neutrophil metabolic heterogeneity in cancer
- Mechanisms of neutrophil metabolic reprogramming in tumor microenvironment
- How neutrophil metabolism affects antitumor immunity
- Markers of neutrophil metabolic heterogeneity in cancer
- Targeting neutrophil metabolic heterogeneity in cancer
Neutrophils have long been recognized as homogeneous cells, but recent evidence has challenged this outdated dogma. High-throughput single-cell methods, including single-cell sequencing and mass spectrometry, have greatly improved our understanding of neutrophil heterogeneity. In tumor microenvironment, both pro-tumoral and anti-tumoral neutrophil subpopulations have been discovered. Although neutrophil subpopulations with distinct immune phenotypes have been reported, a full understanding of neutrophil heterogeneity and the underlying regulatory mechanism remains unclear. In the past decade, metabolic reprogramming of immune cells has attracted much attention. Metabolic reprogramming of neutrophils does not only fulfill the effective energy supply, but also shapes neutrophil immune functions in different pathological conditions. Pro-tumoral and anti-tumoral neutrophil subpopulations are characterized with distinct metabolic status. Investigations into the relationship between neutrophil metabolic heterogeneity and immune phenotypic heterogeneity may favor the understanding of the mechanisms that shape pro-tumoral or anti-tumoral neutrophil subpopulations. Targeting neutrophil metabolic heterogeneity may provide novel therapeutic strategies for tumor immunotherapy.
This Research Topic aims to shed light on investigating neutrophil metabolic heterogeneity in tumor immunotherapy. We welcome contributions in the form of Original Research articles, Reviews and Mini Reviews that cover but are not limited to the following topics related to neutrophil metabolic heterogeneity in cancer.
- Characterization of neutrophil metabolic heterogeneity in cancer
- Mechanisms of neutrophil metabolic reprogramming in tumor microenvironment
- How neutrophil metabolism affects antitumor immunity
- Markers of neutrophil metabolic heterogeneity in cancer
- Targeting neutrophil metabolic heterogeneity in cancer
