The homeostasis in the human digestive and respiratory tract greatly affects human health. Virus-associated infectious disorders are the most common diseases in multiply organs, such as the liver, stomach, intestine, and lung. Upon viral infections, the pattern recognition receptors (PRRs) of the host cells will recognize the pathogenic nucleic acid and initiate the innate immunity signaling to drive the expression of interferons (IFN) to combat the invasion of the viruses. In addition to the anti-viral response, virus-caused imbalance of IFN signaling also causes inflammation-associated cell death and tissue injury. These immune-related diseases, including hepatitis, gastroenteritis, and pneumonia, usually occur in varied viral infections, such as hepatitis B virus (HBV), hepatitis C virus (HCV), enterovirus 71 (EV71), coxsackievirus A16 (CVA16), severe acute respiratory syndrome coronavirus or -2 (SARS-CoV or SARS-CoV-2), influenza A virus (IAV). Therefore, the relationship between IFN signaling and viral pathogenesis is of high concern, which provides essential clues to uncover the mechanisms and therapeutic strategies in these infectious diseases of the digestive and respiratory tract.
Facing the challenges of certain virus-caused digestive and respiratory tract diseases, we organize this Research Topic to provide a forum to advance research on the contribution to the exploration of viral pathogenesis involved in interferon signaling in the digestive and respiratory tract, as well as potential therapeutic interventions on the inflammatory response or cytokine storm during the severe progression of virus-caused digestive and respiratory tract diseases. Here, we welcome manuscripts from, but not limited to, the following subtopics:
1) Mechanisms of interferon induction during viral infections in the digestive and respiratory tract
2) Immune responses to digestive or respiratory virus-induced interferon production
3) Viral pathogenesis involved in interferon signaling in digestive and respiratory tract diseases
4) Drug discovery of virus-caused digestive and respiratory tract diseases targeting interferon signaling pathway or downstream effectors
The homeostasis in the human digestive and respiratory tract greatly affects human health. Virus-associated infectious disorders are the most common diseases in multiply organs, such as the liver, stomach, intestine, and lung. Upon viral infections, the pattern recognition receptors (PRRs) of the host cells will recognize the pathogenic nucleic acid and initiate the innate immunity signaling to drive the expression of interferons (IFN) to combat the invasion of the viruses. In addition to the anti-viral response, virus-caused imbalance of IFN signaling also causes inflammation-associated cell death and tissue injury. These immune-related diseases, including hepatitis, gastroenteritis, and pneumonia, usually occur in varied viral infections, such as hepatitis B virus (HBV), hepatitis C virus (HCV), enterovirus 71 (EV71), coxsackievirus A16 (CVA16), severe acute respiratory syndrome coronavirus or -2 (SARS-CoV or SARS-CoV-2), influenza A virus (IAV). Therefore, the relationship between IFN signaling and viral pathogenesis is of high concern, which provides essential clues to uncover the mechanisms and therapeutic strategies in these infectious diseases of the digestive and respiratory tract.
Facing the challenges of certain virus-caused digestive and respiratory tract diseases, we organize this Research Topic to provide a forum to advance research on the contribution to the exploration of viral pathogenesis involved in interferon signaling in the digestive and respiratory tract, as well as potential therapeutic interventions on the inflammatory response or cytokine storm during the severe progression of virus-caused digestive and respiratory tract diseases. Here, we welcome manuscripts from, but not limited to, the following subtopics:
1) Mechanisms of interferon induction during viral infections in the digestive and respiratory tract
2) Immune responses to digestive or respiratory virus-induced interferon production
3) Viral pathogenesis involved in interferon signaling in digestive and respiratory tract diseases
4) Drug discovery of virus-caused digestive and respiratory tract diseases targeting interferon signaling pathway or downstream effectors